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| Home > Publications database > Determination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (39K) and Sodium (23Na) MRI at 7 T. |
| Home > Publications database > Determination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (39K) and Sodium (23Na) MRI at 7 T. |
| Journal Article | DKFZ-2025-00384 |
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2025
Wiley
New York, NY
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Please use a persistent id in citations: doi:10.1002/nbm.70009
Abstract: Combined 23Na/39K MRI at 7 T can highlight ion disturbances in skeletal muscle tissue. In this work, we investigated if the apparent tissue potassium concentration (aTPC) can be determined in fatty replaced muscles of patients with facio-scapulo-humeral muscular dystrophy (FSHD) and if it can provide additional information to the fat replacement and the apparent tissue sodium concentration (aTSC). The lower leg of 14 patients (six females, eight males; mean age 47.7 ± 14.0 years) with genetically confirmed FSHD and 11 healthy controls (four females, seven males; mean age 47.0 ± 14.0 years) was examined at a 7-T MR system using a dual-tuned 23Na/39K birdcage RF coil. In addition, qualitative and quantitative 1H MR measurements were performed at 7 T to assess the fat replacement and water accumulation. The aTPC and aTSC were determined in seven different muscle regions based on five external references phantoms and corrected for partial volume effects, relaxation biases, and reduced ion concentrations in fat. Results are expressed as median (interquartile range). The measured aTPC was strongly reduced in fat-replaced muscles and was close to zero in totally fat replaced muscles (aTPC = 4.3 mM [2.7 mM] for FF > 80%). After correction of aTPC values for reduced potassium concentration in fat, aTPCfc values of patients in muscles with low or moderate fat fraction (FF < 30%) were similar to values of healthy subjects (patients: aTPCfc = 85.6 mM [21.7 mM]; controls: aTPCfc = 83.2 mM [22.3 mM]). However, muscles with FF > 30% showed reduced aTPCfc and increased aTSCfc compared with healthy controls (aTPCfc = 28.9 mM [46.2 mM], aTSCfc = 42.3 mM [17.6 mM]; controls: aTSCfc = 15.0 mM [4.6 mM], aTPCfc = 83.2 mM [22.3 mM]). No correlations were observed between the aTPCfc and aTSCfc, or between aTPCfc and water T2. We showed that a determination of the aTPC in dystrophic skeletal muscles is feasible using 39K MRI at 7 T. Measured changes in aTPCfc were greater than sole fat replacement and might therefore be used as an additional quantitative measure for dystrophic muscle tissue.
Keyword(s): Humans (MeSH) ; Male (MeSH) ; Female (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Sodium: metabolism (MeSH) ; Muscle, Skeletal: diagnostic imaging (MeSH) ; Muscle, Skeletal: metabolism (MeSH) ; Middle Aged (MeSH) ; Potassium (MeSH) ; Adult (MeSH) ; Phantoms, Imaging (MeSH) ; Sodium Isotopes (MeSH) ; 7 T ; facio‐scapulo‐humeral muscular dystrophy ; potassium MRI ; skeletal muscle ; sodium MRI ; ultrahigh field strength ; Sodium ; Potassium ; Sodium Isotopes
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