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000298950 1001_ $$00000-0002-4599-1122$$aGast, Lena V$$b0
000298950 245__ $$aDetermination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (39K) and Sodium (23Na) MRI at 7 T.
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000298950 520__ $$aCombined 23Na/39K MRI at 7 T can highlight ion disturbances in skeletal muscle tissue. In this work, we investigated if the apparent tissue potassium concentration (aTPC) can be determined in fatty replaced muscles of patients with facio-scapulo-humeral muscular dystrophy (FSHD) and if it can provide additional information to the fat replacement and the apparent tissue sodium concentration (aTSC). The lower leg of 14 patients (six females, eight males; mean age 47.7 ± 14.0 years) with genetically confirmed FSHD and 11 healthy controls (four females, seven males; mean age 47.0 ± 14.0 years) was examined at a 7-T MR system using a dual-tuned 23Na/39K birdcage RF coil. In addition, qualitative and quantitative 1H MR measurements were performed at 7 T to assess the fat replacement and water accumulation. The aTPC and aTSC were determined in seven different muscle regions based on five external references phantoms and corrected for partial volume effects, relaxation biases, and reduced ion concentrations in fat. Results are expressed as median (interquartile range). The measured aTPC was strongly reduced in fat-replaced muscles and was close to zero in totally fat replaced muscles (aTPC = 4.3 mM [2.7 mM] for FF > 80%). After correction of aTPC values for reduced potassium concentration in fat, aTPCfc values of patients in muscles with low or moderate fat fraction (FF < 30%) were similar to values of healthy subjects (patients: aTPCfc = 85.6 mM [21.7 mM]; controls: aTPCfc = 83.2 mM [22.3 mM]). However, muscles with FF > 30% showed reduced aTPCfc and increased aTSCfc compared with healthy controls (aTPCfc = 28.9 mM [46.2 mM], aTSCfc = 42.3 mM [17.6 mM]; controls: aTSCfc = 15.0 mM [4.6 mM], aTPCfc = 83.2 mM [22.3 mM]). No correlations were observed between the aTPCfc and aTSCfc, or between aTPCfc and water T2. We showed that a determination of the aTPC in dystrophic skeletal muscles is feasible using 39K MRI at 7 T. Measured changes in aTPCfc were greater than sole fat replacement and might therefore be used as an additional quantitative measure for dystrophic muscle tissue.
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000298950 650_7 $$2Other$$a7 T
000298950 650_7 $$2Other$$afacio‐scapulo‐humeral muscular dystrophy
000298950 650_7 $$2Other$$apotassium MRI
000298950 650_7 $$2Other$$askeletal muscle
000298950 650_7 $$2Other$$asodium MRI
000298950 650_7 $$2Other$$aultrahigh field strength
000298950 650_7 $$09NEZ333N27$$2NLM Chemicals$$aSodium
000298950 650_7 $$0RWP5GA015D$$2NLM Chemicals$$aPotassium
000298950 650_7 $$2NLM Chemicals$$aSodium Isotopes
000298950 650_2 $$2MeSH$$aHumans
000298950 650_2 $$2MeSH$$aMale
000298950 650_2 $$2MeSH$$aFemale
000298950 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000298950 650_2 $$2MeSH$$aSodium: metabolism
000298950 650_2 $$2MeSH$$aMuscle, Skeletal: diagnostic imaging
000298950 650_2 $$2MeSH$$aMuscle, Skeletal: metabolism
000298950 650_2 $$2MeSH$$aMiddle Aged
000298950 650_2 $$2MeSH$$aPotassium
000298950 650_2 $$2MeSH$$aAdult
000298950 650_2 $$2MeSH$$aPhantoms, Imaging
000298950 650_2 $$2MeSH$$aSodium Isotopes
000298950 7001_ $$aGerhalter, Teresa$$b1
000298950 7001_ $$aTürk, Matthias$$b2
000298950 7001_ $$aSapli, Alper$$b3
000298950 7001_ $$aMathy, Claudius S$$b4
000298950 7001_ $$00000-0002-2897-5411$$aHeiss, Rafael$$b5
000298950 7001_ $$00000-0001-8955-4648$$aBaudin, Pierre-Yves$$b6
000298950 7001_ $$00000-0002-4983-647X$$aMarty, Benjamin$$b7
000298950 7001_ $$aUder, Michael$$b8
000298950 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin$$b9$$eLast author$$udkfz
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