Journal Article (Review Article)

DKFZ-2025-00418

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The landscape of immune monitoring in CAR-T cell therapy: A comprehensive review and survey study by the Cellular Therapy and Immunobiology Working Party of the EBMT.

Pagliuca, S. ; Malard, F. ; Mooyaart, J. E. ; Daskalakis, M. ; Gabellier, L. ; Yakoub-Agha, I. ; Ram, R. ; Besley, C. ; Forcade, E. ; Vucinic, V. ; Corral, L. L. ; Vydra, J. ; von Tresckow, B.DKFZ* ; Amat, P. ; Amrolia, P. ; Vandenberghe, P. ; Stölzel, F. ; Sica, S. ; Rubio, M. T. ; Hoogenboom, J. D. ; Ortiz-Maldonado, V. ; Nagler, A. ; Kuball, J. ; Chabannon, C. ; Ruggeri, A.

2025
Harcourt Burlington, Mass.

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Please use a persistent id in citations: doi:10.1016/j.blre.2025.101272

Abstract: Immune monitoring of cell therapies is a complex and evolving topic, particularly in the rapid expanding field of chimeric antigen receptor T (CAR-T) cell applications. Defining essential, recommended, and optional immune monitoring data post-CAR-T cell infusion is crucial to improve patient outcomes and inform post-treatment decisions. To address this gap, we conducted a survey-based study across centers affiliated with the European Society for Blood and Marrow Transplantation (EBMT), focusing on patients treated with European Medicines Agency (EMA)-approved CAR-T products. Building on a thorough review of the literature, we mapped the current landscape of immune monitoring practices and assessed their impact on clinical management. By defining the state of the art in the field, this work marks an initial step towards a structured harmonization process potentially able to enhance the management and outcomes of patients undergoing these immune cell therapies.

Keyword(s): B cell aplasia ; CAR-T cell expansion ; CAR-T cells ; CRS ; ICANS ; Immune monitoring ; Immune reconstitution ; Lentiviral integration ; Transduction

Note: Volume 71, May 2025, 101272

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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