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000299522 041__ $$aEnglish
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000299522 1001_ $$0P:(DE-He78)a2efd829a4ed4177427f4ceeafa06a3c$$aWinkelkotte, Alina$$b0$$eFirst author$$udkfz
000299522 245__ $$aInteractions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer.
000299522 260__ $$aCold Spring Harbor, NY$$bCold Spring Harbor Laboratory Press$$c2025
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000299522 520__ $$aLipids have essential functions as structural components of cellular membranes, as efficient energy storage molecules, and as precursors of signaling mediators. While deregulated glucose and amino acid metabolism in cancer have received substantial attention, the roles of lipids in the metabolic reprogramming of cancer cells are less well understood. However, since the first description of de novo fatty acid biosynthesis in cancer tissues almost 70 years ago, numerous studies have investigated the complex functions of altered lipid metabolism in cancer. Here, we will summarize the mechanisms by which oncogenic signaling pathways regulate fatty acid and cholesterol metabolism to drive rapid proliferation and protect cancer cells from environmental stress. The review also discusses the role of fatty acid metabolism in metabolic plasticity required for the adaptation to changing microenvironments during cancer progression and the connections between fatty acid and cholesterol metabolism and ferroptosis.
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000299522 650_7 $$2NLM Chemicals$$aFatty Acids
000299522 650_7 $$097C5T2UQ7J$$2NLM Chemicals$$aCholesterol
000299522 650_2 $$2MeSH$$aHumans
000299522 650_2 $$2MeSH$$aNeoplasms: metabolism
000299522 650_2 $$2MeSH$$aNeoplasms: pathology
000299522 650_2 $$2MeSH$$aFatty Acids: metabolism
000299522 650_2 $$2MeSH$$aCholesterol: metabolism
000299522 650_2 $$2MeSH$$aSignal Transduction
000299522 650_2 $$2MeSH$$aLipid Metabolism
000299522 650_2 $$2MeSH$$aStress, Physiological: physiology
000299522 650_2 $$2MeSH$$aAnimals
000299522 650_2 $$2MeSH$$aFerroptosis
000299522 650_2 $$2MeSH$$aTumor Microenvironment
000299522 7001_ $$0P:(DE-He78)b7a0487a60da451c67d4b0fef6641ed8$$aAl-Shami, Kamal$$b1$$udkfz
000299522 7001_ $$0P:(DE-HGF)0$$aChaves-Filho, Adriano B$$b2
000299522 7001_ $$0P:(DE-He78)38900a0e1ae96a725db546cb7b909adb$$aVogel, Felix C E$$b3$$udkfz
000299522 7001_ $$0P:(DE-He78)94ae391f53fb9285e1b68f9930615af1$$aSchulze, Almut$$b4$$eLast author$$udkfz
000299522 773__ $$0PERI:(DE-600)2628603-8$$a10.1101/cshperspect.a041548$$gVol. 15, no. 3, p. a041548 -$$n3$$pa041548$$tCold Spring Harbor perspectives in medicine$$v15$$x2157-1422$$y2025
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