Journal Article (Review Article)

DKFZ-2025-00480

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer.

Winkelkotte, A. (First author)DKFZ* ; Al-Shami, K.DKFZ* ; Chaves-Filho, A. B.DKFZ* ; Vogel, F. C. E.DKFZ* ; Schulze, A. (Last author)DKFZ*

2025
Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY

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Please use a persistent id in citations: doi:10.1101/cshperspect.a041548

Abstract: Lipids have essential functions as structural components of cellular membranes, as efficient energy storage molecules, and as precursors of signaling mediators. While deregulated glucose and amino acid metabolism in cancer have received substantial attention, the roles of lipids in the metabolic reprogramming of cancer cells are less well understood. However, since the first description of de novo fatty acid biosynthesis in cancer tissues almost 70 years ago, numerous studies have investigated the complex functions of altered lipid metabolism in cancer. Here, we will summarize the mechanisms by which oncogenic signaling pathways regulate fatty acid and cholesterol metabolism to drive rapid proliferation and protect cancer cells from environmental stress. The review also discusses the role of fatty acid metabolism in metabolic plasticity required for the adaptation to changing microenvironments during cancer progression and the connections between fatty acid and cholesterol metabolism and ferroptosis.

Keyword(s): Humans (MeSH) ; Neoplasms: metabolism (MeSH) ; Neoplasms: pathology (MeSH) ; Fatty Acids: metabolism (MeSH) ; Cholesterol: metabolism (MeSH) ; Signal Transduction (MeSH) ; Lipid Metabolism (MeSH) ; Stress, Physiological: physiology (MeSH) ; Animals (MeSH) ; Ferroptosis (MeSH) ; Tumor Microenvironment (MeSH) ; Fatty Acids ; Cholesterol

Note: #EA:A410#LA:A410#

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Contributing Institute(s):

1. Metabolismus und Microenvironment (A410)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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