TY  - JOUR
AU  - Winkelkotte, Alina
AU  - Al-Shami, Kamal
AU  - Chaves-Filho, Adriano B
AU  - Vogel, Felix C E
AU  - Schulze, Almut
TI  - Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer.
JO  - Cold Spring Harbor perspectives in medicine
VL  - 15
IS  - 3
SN  - 2157-1422
CY  - Cold Spring Harbor, NY
PB  - Cold Spring Harbor Laboratory Press
M1  - DKFZ-2025-00480
SP  - a041548
PY  - 2025
N1  - #EA:A410#LA:A410#
AB  - Lipids have essential functions as structural components of cellular membranes, as efficient energy storage molecules, and as precursors of signaling mediators. While deregulated glucose and amino acid metabolism in cancer have received substantial attention, the roles of lipids in the metabolic reprogramming of cancer cells are less well understood. However, since the first description of de novo fatty acid biosynthesis in cancer tissues almost 70 years ago, numerous studies have investigated the complex functions of altered lipid metabolism in cancer. Here, we will summarize the mechanisms by which oncogenic signaling pathways regulate fatty acid and cholesterol metabolism to drive rapid proliferation and protect cancer cells from environmental stress. The review also discusses the role of fatty acid metabolism in metabolic plasticity required for the adaptation to changing microenvironments during cancer progression and the connections between fatty acid and cholesterol metabolism and ferroptosis.
KW  - Humans
KW  - Neoplasms: metabolism
KW  - Neoplasms: pathology
KW  - Fatty Acids: metabolism
KW  - Cholesterol: metabolism
KW  - Signal Transduction
KW  - Lipid Metabolism
KW  - Stress, Physiological: physiology
KW  - Animals
KW  - Ferroptosis
KW  - Tumor Microenvironment
KW  - Fatty Acids (NLM Chemicals)
KW  - Cholesterol (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38951029
C2  - pmc:PMC11875093
DO  - DOI:10.1101/cshperspect.a041548
UR  - https://inrepo02.dkfz.de/record/299522
ER  -