% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Winkelkotte:299522,
      author       = {A. Winkelkotte$^*$ and K. Al-Shami$^*$ and A. B.
                      Chaves-Filho$^*$ and F. C. E. Vogel$^*$ and A. Schulze$^*$},
      title        = {{I}nteractions of {F}atty {A}cid and {C}holesterol
                      {M}etabolism with {C}ellular {S}tress {R}esponse {P}athways
                      in {C}ancer.},
      journal      = {Cold Spring Harbor perspectives in medicine},
      volume       = {15},
      number       = {3},
      issn         = {2157-1422},
      address      = {Cold Spring Harbor, NY},
      publisher    = {Cold Spring Harbor Laboratory Press},
      reportid     = {DKFZ-2025-00480},
      pages        = {a041548},
      year         = {2025},
      note         = {#EA:A410#LA:A410#},
      abstract     = {Lipids have essential functions as structural components of
                      cellular membranes, as efficient energy storage molecules,
                      and as precursors of signaling mediators. While deregulated
                      glucose and amino acid metabolism in cancer have received
                      substantial attention, the roles of lipids in the metabolic
                      reprogramming of cancer cells are less well understood.
                      However, since the first description of de novo fatty acid
                      biosynthesis in cancer tissues almost 70 years ago, numerous
                      studies have investigated the complex functions of altered
                      lipid metabolism in cancer. Here, we will summarize the
                      mechanisms by which oncogenic signaling pathways regulate
                      fatty acid and cholesterol metabolism to drive rapid
                      proliferation and protect cancer cells from environmental
                      stress. The review also discusses the role of fatty acid
                      metabolism in metabolic plasticity required for the
                      adaptation to changing microenvironments during cancer
                      progression and the connections between fatty acid and
                      cholesterol metabolism and ferroptosis.},
      subtyp        = {Review Article},
      keywords     = {Humans / Neoplasms: metabolism / Neoplasms: pathology /
                      Fatty Acids: metabolism / Cholesterol: metabolism / Signal
                      Transduction / Lipid Metabolism / Stress, Physiological:
                      physiology / Animals / Ferroptosis / Tumor Microenvironment
                      / Fatty Acids (NLM Chemicals) / Cholesterol (NLM Chemicals)},
      cin          = {A410},
      ddc          = {610},
      cid          = {I:(DE-He78)A410-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38951029},
      pmc          = {pmc:PMC11875093},
      doi          = {10.1101/cshperspect.a041548},
      url          = {https://inrepo02.dkfz.de/record/299522},
}