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001     299522
005     20250311104404.0
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|a 2157-1422
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|a 2472-5412
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041 _ _ |a English
082 _ _ |a 610
100 1 _ |0 P:(DE-He78)a2efd829a4ed4177427f4ceeafa06a3c
|a Winkelkotte, Alina
|b 0
|e First author
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245 _ _ |a Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer.
260 _ _ |a Cold Spring Harbor, NY
|b Cold Spring Harbor Laboratory Press
|c 2025
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520 _ _ |a Lipids have essential functions as structural components of cellular membranes, as efficient energy storage molecules, and as precursors of signaling mediators. While deregulated glucose and amino acid metabolism in cancer have received substantial attention, the roles of lipids in the metabolic reprogramming of cancer cells are less well understood. However, since the first description of de novo fatty acid biosynthesis in cancer tissues almost 70 years ago, numerous studies have investigated the complex functions of altered lipid metabolism in cancer. Here, we will summarize the mechanisms by which oncogenic signaling pathways regulate fatty acid and cholesterol metabolism to drive rapid proliferation and protect cancer cells from environmental stress. The review also discusses the role of fatty acid metabolism in metabolic plasticity required for the adaptation to changing microenvironments during cancer progression and the connections between fatty acid and cholesterol metabolism and ferroptosis.
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650 _ 7 |2 NLM Chemicals
|a Fatty Acids
650 _ 7 |0 97C5T2UQ7J
|2 NLM Chemicals
|a Cholesterol
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Neoplasms: metabolism
650 _ 2 |2 MeSH
|a Neoplasms: pathology
650 _ 2 |2 MeSH
|a Fatty Acids: metabolism
650 _ 2 |2 MeSH
|a Cholesterol: metabolism
650 _ 2 |2 MeSH
|a Signal Transduction
650 _ 2 |2 MeSH
|a Lipid Metabolism
650 _ 2 |2 MeSH
|a Stress, Physiological: physiology
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Ferroptosis
650 _ 2 |2 MeSH
|a Tumor Microenvironment
700 1 _ |0 P:(DE-He78)b7a0487a60da451c67d4b0fef6641ed8
|a Al-Shami, Kamal
|b 1
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700 1 _ |0 P:(DE-HGF)0
|a Chaves-Filho, Adriano B
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700 1 _ |0 P:(DE-He78)38900a0e1ae96a725db546cb7b909adb
|a Vogel, Felix C E
|b 3
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700 1 _ |0 P:(DE-He78)94ae391f53fb9285e1b68f9930615af1
|a Schulze, Almut
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|e Last author
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