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@ARTICLE{Daud:299552,
      author       = {E. Daud and R. F. Trauzeddel and M. Müller and L. T. W.
                      Vestjens and J. Gröschel and D. Viezzer and T. Hadler and
                      E. Blaszczyk and N. Jin and D. Giese and S. Schmitter$^*$
                      and J. Schulz-Menger},
      title        = {{A}ssessing reliability and comparability of 4{D} flow
                      {CMR} whole heart measurements using retrospective valve
                      tracking: {A} single-vendor study in the {B}erlin research
                      network.},
      journal      = {Magnetic resonance imaging},
      volume       = {119},
      issn         = {0730-725X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-00496},
      pages        = {110368},
      year         = {2025},
      note         = {Volume 119, June 2025, 110368},
      abstract     = {This study investigated intracardiac flow dynamics and
                      assessed the comparability and reliability of 4D flow CMR
                      measurements across multiple sites within the Berlin
                      Research Network for Cardiovascular Magnetic Resonance
                      (BER-CMR) using 3D cine phase-contrast imaging with
                      three-directional velocity encoding in a healthy traveling
                      cohort.In a prospective multi-site cohort study, 20 healthy
                      volunteers underwent CMR at different sites. Quantitative
                      assessment of Forward flow Volume (FFV), Peak (PV) and Mean
                      Velocity (MV) across the heart's valves were conducted using
                      retrospective valve tracking. FFV of the aortic and
                      pulmonary valves, measured via 4D flow CMR, was compared to
                      each other and to Stroke Volume (SV) from cine imaging.
                      Reliability was assessed using scan-rescan tolerance ranges
                      from a single site, with equivalency assumed if other sites'
                      confidence intervals fell within these ranges. Intra- and
                      interobserver analyses evaluated measurement consistency.The
                      final analysis included 19 healthy volunteers. Intersite
                      comparability analysis across all four heart valves revealed
                      a strong reliability for FFV, PV and MV, except for FFV at
                      the mitral valve at two sites and PV at the tricuspid valve
                      at one site. Correlation analysis of SV and FFV of the
                      corresponding ventriculoarterial valves demonstrated good
                      agreement (aortic valve: r = 0.89, P < 0.001; pulmonary
                      valve: r = 0.88, p < 0.001). Inter- and intraobserver
                      analyses yielded good to excellent agreement across all
                      valves (ICC > 0.90, p < 0.001).4D flow CMR whole-heart
                      measurements in healthy volunteers were consistent across
                      sites, showing strong agreement despite physiological and
                      technical variability. These findings support future
                      multicenter studies.},
      keywords     = {4D flow CMR (Other) / Cardiovascular magnetic resonance
                      imaging (Other) / Healthy volunteers (Other) / Reliability
                      (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40049254},
      doi          = {10.1016/j.mri.2025.110368},
      url          = {https://inrepo02.dkfz.de/record/299552},
}