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000299574 1001_ $$aCelik, Gulustan$$b0
000299574 245__ $$aSignaling to survive: linear ubiquitination in health and disease
000299574 260__ $$aHeidelberg$$bSpringer Nature$$c2025
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000299574 520__ $$aPost-translational modification with ubiquitin (Ub) controls protein stability, localization and function and occurs as single entity, or as poly-Ub chains, linked via lysine residues or the N-terminal methionine (M1 poly-Ub). Generated by the linear ubiquitin chain assembly complex (LUBAC) and counteracted by the deubiquitinating enzymes OTULIN and CYLD, M1 poly-Ub controls immune signaling, survival and cell death. Here, we discuss old and new functions of M1 poly-Ub in health and disease.
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000299574 7001_ $$aWeinelt, Nadine$$b1
000299574 7001_ $$0P:(DE-He78)98a5742a78e40532532721c840cbd132$$avan Wijk, Sjoerd$$b2
000299574 773__ $$0PERI:(DE-600)2203536-9$$a10.1007/s12268-025-2402-3$$gVol. 31, no. 1, p. 32 - 35$$n1$$p32 - 35$$tBiospektrum$$v31$$x0947-0867$$y2025
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