Journal Article

DKFZ-2025-00515

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Signaling to survive: linear ubiquitination in health and disease

Celik, G. ; Weinelt, N. ; van Wijk, S.DKFZ*

2025
Springer Nature Heidelberg

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Please use a persistent id in citations: doi:10.1007/s12268-025-2402-3

Abstract: Post-translational modification with ubiquitin (Ub) controls protein stability, localization and function and occurs as single entity, or as poly-Ub chains, linked via lysine residues or the N-terminal methionine (M1 poly-Ub). Generated by the linear ubiquitin chain assembly complex (LUBAC) and counteracted by the deubiquitinating enzymes OTULIN and CYLD, M1 poly-Ub controls immune signaling, survival and cell death. Here, we discuss old and new functions of M1 poly-Ub in health and disease.

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Frankfurt (FM01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; DEAL Springer ; DEAL Springer ; SCOPUS

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