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037 _ _ |a DKFZ-2025-00515
041 _ _ |a English
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100 1 _ |a Celik, Gulustan
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245 _ _ |a Signaling to survive: linear ubiquitination in health and disease
260 _ _ |a Heidelberg
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520 _ _ |a Post-translational modification with ubiquitin (Ub) controls protein stability, localization and function and occurs as single entity, or as poly-Ub chains, linked via lysine residues or the N-terminal methionine (M1 poly-Ub). Generated by the linear ubiquitin chain assembly complex (LUBAC) and counteracted by the deubiquitinating enzymes OTULIN and CYLD, M1 poly-Ub controls immune signaling, survival and cell death. Here, we discuss old and new functions of M1 poly-Ub in health and disease.
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700 1 _ |a Weinelt, Nadine
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700 1 _ |a van Wijk, Sjoerd
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773 _ _ |a 10.1007/s12268-025-2402-3
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