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@ARTICLE{Betzler:300190,
      author       = {A. Betzler and J. Betzler$^*$ and A. Bogner and E. Walther
                      and M. Rahbari and C. Reissfelder and C. Riediger and J.
                      Weitz and N. N. Rahbari and E. Birgin},
      title        = {{L}ong-term diuretic medication is an independent predictor
                      of posthepatectomy liver failure},
      journal      = {Journal of gastrointestinal surgery},
      volume       = {29},
      number       = {5},
      issn         = {1091-255X},
      address      = {[Amsterdam]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00667},
      pages        = {102035},
      year         = {2025},
      note         = {#EA:B440# / 2025 Mar 26;29(5):102035},
      abstract     = {Posthepatectomy liver failure (PHLF) is the most fatal
                      complication following liver resection, particularly, in
                      patients with comorbidities. This study aimed to assess the
                      impact of long-term medication on PHLF incidence after open
                      liver resections.A retrospective analysis of 682 patients
                      who underwent elective open hepatectomies between 2008 and
                      2015 at two academic centers was performed. Preoperative,
                      intraoperative, and postoperative data were collected,
                      including long-term medication. Risk factors for the
                      development of PHLF and other postoperative complications
                      were evaluated using univariate and multivariable logistic
                      regression analyses.PHLF occurred in $11.9\%$ (n=81) of
                      patients, with a higher incidence in those taking diuretics
                      as long-term medication $(17.7\%$ vs. $5.3\%,$ P < 0.001).
                      Diuretic use was identified as a strong independent risk
                      factor for PHLF (OR 3.8, $95\%CI$ 2.1 - 7.0, P < 0.001),
                      alongside liver cirrhosis (OR 3.8, $95\%CI$ 1.9 - 7.6, P <
                      0.001), primary liver malignancies (OR 3.8, $95\%CI$ 1.6 -
                      9.3, P < 0.001), major hepatectomies (OR 3.1, $95\%CI$ 1.7 -
                      5.7, P < 0.001) and long operating time (OR 4.2, $95\%$ CI
                      2.4 - 7.2, P < 0.001). Patients with long-term diuretic
                      intake were older, had higher BMIs, and more comorbidities,
                      including liver cirrhosis.Long-term diuretic use is
                      associated with a significantly increased risk of PHLF after
                      open hepatectomy.},
      keywords     = {ISGLS (Other) / comedication (Other) / comorbidity (Other)
                      / hepatectomy (Other) / multimorbidity (Other)},
      cin          = {B440},
      ddc          = {610},
      cid          = {I:(DE-He78)B440-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40154837},
      doi          = {10.1016/j.gassur.2025.102035},
      url          = {https://inrepo02.dkfz.de/record/300190},
}