Journal Article

DKFZ-2025-00667

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Long-term diuretic medication is an independent predictor of posthepatectomy liver failure

Betzler, A. ; Betzler, J. (First author)DKFZ* ; Bogner, A. ; Walther, E. ; Rahbari, M. ; Reissfelder, C. ; Riediger, C. ; Weitz, J. ; Rahbari, N. N. ; Birgin, E.

2025
Elsevier [Amsterdam]

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Please use a persistent id in citations: doi:10.1016/j.gassur.2025.102035

Abstract: Posthepatectomy liver failure (PHLF) is the most fatal complication following liver resection, particularly, in patients with comorbidities. This study aimed to assess the impact of long-term medication on PHLF incidence after open liver resections.A retrospective analysis of 682 patients who underwent elective open hepatectomies between 2008 and 2015 at two academic centers was performed. Preoperative, intraoperative, and postoperative data were collected, including long-term medication. Risk factors for the development of PHLF and other postoperative complications were evaluated using univariate and multivariable logistic regression analyses.PHLF occurred in 11.9% (n=81) of patients, with a higher incidence in those taking diuretics as long-term medication (17.7% vs. 5.3%, P < 0.001). Diuretic use was identified as a strong independent risk factor for PHLF (OR 3.8, 95%CI 2.1 - 7.0, P < 0.001), alongside liver cirrhosis (OR 3.8, 95%CI 1.9 - 7.6, P < 0.001), primary liver malignancies (OR 3.8, 95%CI 1.6 - 9.3, P < 0.001), major hepatectomies (OR 3.1, 95%CI 1.7 - 5.7, P < 0.001) and long operating time (OR 4.2, 95% CI 2.4 - 7.2, P < 0.001). Patients with long-term diuretic intake were older, had higher BMIs, and more comorbidities, including liver cirrhosis.Long-term diuretic use is associated with a significantly increased risk of PHLF after open hepatectomy.

Keyword(s): ISGLS ; comedication ; comorbidity ; hepatectomy ; multimorbidity

Note: #EA:B440# / 2025 Mar 26;29(5):102035

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Contributing Institute(s):

1. NWG-KKE Translationale Gastrointestinale Onkologie und präklinische Modelle (B440)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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