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@ARTICLE{Consortium:300223,
author = {C. Magnussen and J. Alegre-Diaz and L. A. Al-Nasser and P.
Amouyel and L. Aviles-Santa and S. J. L. Bakker and C. M.
Ballantyne and A. Bernabé-Ortiz and M. Bobak and P.
Boffetta and H. Brenner$^*$ and M. Brunström and G. Can and
R. M. Carrillo-Larco and W. Checkley and J. Dallongeville
and D. De Bacquer and G. de Gaetano and J. A. de Lemos and
E. di Carluccio and A. Dobson and C. Donfrancesco and M.
Dörr and E. d'Orsi and W. Drygas and R. P. F. Dullaart and
G. Engström and M. M. Ferrario and J. Ferrières and G. A.
Figtree and B. Gaye and M. Ghayour-Mobarhan and U. Goldbourt
and C. Gonzalez and A. Gossling and G. Grassi and P. C.
Gupta and J. He and A. M. Hodge and A. Hozawa and K. Hveem
and L. Iacoviello and M. K. Ikram and M. Inoue and V.
Irazola and M. Jobe and P. Jousilahti and P. Kaleebu and M.
Kavousi and F. Kee and D. Khalili and J. Klotsche and W.
Koenig and A. Kontsevaya and S. Kowlessur and P.
Kuri-Morales and K. Kuulasmaa and S.-S. Kweon and K. J.
Lackner and U. Landmesser and D. M. Leistner and C. E. Leiva
Sisnieguez and D. Leong and L. Lind and A. Linneberg and T.
Lorenz and M. N. Lyngbakken and R. Malekzadeh and S.
Malyutina and E. B. Mathiesen and P. McElduff and O.
Melander and A. Metspalu and J. J. Miranda and M. Moitry and
J. Mugisha and J. Munzinger and M. Nalini and V. Nambi and
P. M. Nilsson and T. Ninomiya and T. Omland and S. K. Ong
and K. Oppermann and A. Pajak and L. Palmieri and D.
Panagiotakos and S. K. Park and M. S. Pednekar and A.
Perianayagam and A. Peters and H. Poustchi and D.
Prabhakaran and A. M. Prentice and E. Prescott and A.
Quyyumi and U. Risérus and S. Sakata and M. Salazar and V.
Salomaa and S. Sans and E. L. P. Sattler and B.
Schöttker$^*$ and A. E. Schutte and S. G. Sepanlou and S.
K. Sharma and J. Shaw and L. A. Simons and S. Söderberg and
A. Tamosiunas and R. Tapia-Conyer and B. Thorand and H.
Tunstall-Pedoe and J. Tuomilehto and R. Twerenbold and D.
Vanuzzo and G. Veronesi and S. G. Wannamethee and M.
Watanabe and J. Weimann and P. S. Wild and Y. Yao and Y.
Zeng and A. Ziegler and F. M. Ojeda and S. Blankenberg},
collaboration = {G. C. R. Consortium},
title = {{G}lobal {E}ffect of {C}ardiovascular {R}isk {F}actors on
{L}ifetime {E}stimates.},
journal = {The New England journal of medicine},
volume = {393},
number = {2},
issn = {0028-4793},
address = {Waltham, Mass.},
publisher = {MMS},
reportid = {DKFZ-2025-00685},
pages = {125-138},
year = {2025},
note = {2025 Jul 10;393(2):125-138},
abstract = {Five risk factors account for approximately $50\%$ of the
global burden of cardiovascular disease. How the presence or
absence of classic risk factors affects lifetime estimates
of cardiovascular disease and death from any cause remains
unclear.We harmonized individual-level data from 2,078,948
participants across 133 cohorts, 39 countries, and 6
continents. Lifetime risk of cardiovascular disease and
death from any cause was estimated up to 90 years of age
according to the presence or absence of arterial
hypertension, hyperlipidemia, underweight and overweight or
obesity, diabetes, and smoking at 50 years of age.
Differences in life span (in terms of additional life-years
free of cardiovascular disease or death from any cause)
according to the presence or absence of these risk factors
were also estimated. Risk-factor trajectories were analyzed
to predict lifetime differences according to risk-factor
variation.The lifetime risk of cardiovascular disease was
$24\%$ $(95\%$ confidence interval [CI], 21 to 30) among
women and $38\%$ $(95\%$ CI, 30 to 45) among men for whom
all five risk factors were present. In the comparison
between participants with none of the risk factors and those
with all the risk factors, the estimated number of
additional life-years free of cardiovascular disease was
13.3 $(95\%$ CI, 11.2 to 15.7) for women and 10.6 $(95\%$
CI, 9.2 to 12.9) for men; the estimated number of additional
life-years free of death was 14.5 $(95\%$ CI, 9.1 to 15.3)
for women and 11.8 $(95\%$ CI, 10.1 to 13.6) for men. As
compared with no changes in the presence of all risk
factors, modification of hypertension at an age of 55 to
less than 60 years was associated with the most additional
life-years free of cardiovascular disease, and modification
of smoking at an age of 55 to less than 60 years was
associated with the most additional life-years free of
death.The absence of five classic risk factors at 50 years
of age was associated with more than a decade greater life
expectancy than the presence of all five risk factors, in
both sexes. Persons who modified hypertension and smoking in
midlife had the most additional life-years free of
cardiovascular disease and death from any cause,
respectively. (Funded by the German Center for
Cardiovascular Research [DZHK]; ClinicalTrials.gov number,
NCT05466825.).},
cin = {C070},
ddc = {610},
cid = {I:(DE-He78)C070-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40162648},
doi = {10.1056/NEJMoa2415879},
url = {https://inrepo02.dkfz.de/record/300223},
}
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