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| Home > Publications database > Feasibility study of using fast low-dose pencil beam proton and helium radiographs for intrafractional motion management. |
| Journal Article | DKFZ-2025-00693 |
; ; ; ; ; ; ;
2025
Elsevier
Amsterdam
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Please use a persistent id in citations: doi:10.1016/j.ejmp.2025.104959
Abstract: This study aims to evaluate the feasibility of using fast, low-dose proton (pRad) and helium (HeRad) radiography for intrafractional motion management. This approach uses pencil ion beam delivery systems, modern particle imaging detectors and fast image reconstruction.A plastic respiratory phantom underwent four-dimensional computed tomography (4DCT) using a commercial X-ray scanner, experimental pRad with a continuous proton beam from a clinical serial cyclotron, and experimental pRad and HeRad with pulsed proton and helium beams from a synchrotron-based ion therapy facility. Open-source patient 4DCT data were used in a Monte Carlo simulation study to evaluate pRad and HeRad in a realistic patient geometry. Treatment plans involving mixed carbon-helium beams were calculated using matRad and simulated in TOPAS.The experimental pRad achieved a temporal resolution of 8 fps for the cyclotron-based facility, while both pRad and HeRad achieved 2 fps for the synchrotron-based facility within a 10 cm × 10 cm region of interest. pRad reconstructed the respiratory phantom motion pattern with a dose of less than 2 µGy per image. In simulations of mixed carbon-helium beams, HeRad, both integral and single iso-energy, detected water equivalent thickness differences with sub-millimeter accuracy across different phases of the patient's 4DCT data.This study demonstrates that low-dose small-field proton and helium radiography, utilizing pencil beam scanning, can effectively monitor intrafractional anatomical displacements with millimeter-level spatial accuracy and sub-second temporal resolution. Current particle imaging and beam delivery technologies have the potential to enable real-time patient monitoring in promising mixed ion beam therapy.
Keyword(s): Adaptive radiation therapy ; Helium imaging ; Ion beam therapy ; Motion management ; Proton imaging ; Proton therapy
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