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000300347 1001_ $$00000-0001-7920-7001$$aGilbert, Jack A$$b0
000300347 245__ $$aClinical translation of microbiome research.
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000300347 520__ $$aThe landscape of clinical microbiome research has dramatically evolved over the past decade. By leveraging in vivo and in vitro experimentation, multiomic approaches and computational biology, we have uncovered mechanisms of action and microbial metrics of association and identified effective ways to modify the microbiome in many diseases and treatment modalities. This Review explores recent advances in the clinical application of microbiome research over the past 5 years, while acknowledging existing barriers and highlighting opportunities. We focus on the translation of microbiome research into clinical practice, spearheaded by Food and Drug Administration (FDA)-approved microbiome therapies for recurrent Clostridioides difficile infections and the emerging fields of microbiome-based diagnostics and therapeutics. We highlight key examples of studies demonstrating how microbiome mechanisms, metrics and modifiers can advance clinical practice. We also discuss forward-looking perspectives on key challenges and opportunities toward integrating microbiome data into routine clinical practice, precision medicine and personalized healthcare and nutrition.
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000300347 7001_ $$00000-0002-5942-4444$$aAzad, Meghan B$$b1
000300347 7001_ $$aBäckhed, Fredrik$$b2
000300347 7001_ $$00000-0003-2447-2443$$aBlaser, Martin J$$b3
000300347 7001_ $$aByndloss, Mariana$$b4
000300347 7001_ $$00000-0003-2915-2094$$aChiu, Charles Y$$b5
000300347 7001_ $$aChu, Hiutung$$b6
000300347 7001_ $$aDugas, Lara R$$b7
000300347 7001_ $$0P:(DE-He78)725ad944da4e1ea60389fe9dbbed2c7c$$aElinav, Eran$$b8$$udkfz
000300347 7001_ $$00000-0002-8724-7916$$aGibbons, Sean M$$b9
000300347 7001_ $$aGilbert, Katharine E$$b10
000300347 7001_ $$aHenn, Matthew R$$b11
000300347 7001_ $$00000-0002-2615-8055$$aIshaq, Suzanne L$$b12
000300347 7001_ $$00000-0002-9087-1672$$aLey, Ruth E$$b13
000300347 7001_ $$00000-0001-5695-7336$$aLynch, Susan V$$b14
000300347 7001_ $$00000-0002-6859-1164$$aSegal, Eran$$b15
000300347 7001_ $$aSpector, Tim D$$b16
000300347 7001_ $$aStrandwitz, Philip$$b17
000300347 7001_ $$00000-0003-3836-972X$$aSuez, Jotham$$b18
000300347 7001_ $$00000-0002-7542-1577$$aTropini, Carolina$$b19
000300347 7001_ $$aWhiteson, Katrine$$b20
000300347 7001_ $$aKnight, Rob$$b21
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