Journal Article (Review Article)

DKFZ-2025-00781

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Clinical translation of microbiome research.

Gilbert, J. A. ; Azad, M. B. ; Bäckhed, F. ; Blaser, M. J. ; Byndloss, M. ; Chiu, C. Y. ; Chu, H. ; Dugas, L. R. ; Elinav, E.DKFZ* ; Gibbons, S. M. ; Gilbert, K. E. ; Henn, M. R. ; Ishaq, S. L. ; Ley, R. E. ; Lynch, S. V. ; Segal, E. ; Spector, T. D. ; Strandwitz, P. ; Suez, J. ; Tropini, C. ; Whiteson, K. ; Knight, R.

2025
Springer Nature [New York, NY]

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Please use a persistent id in citations: doi:10.1038/s41591-025-03615-9

Abstract: The landscape of clinical microbiome research has dramatically evolved over the past decade. By leveraging in vivo and in vitro experimentation, multiomic approaches and computational biology, we have uncovered mechanisms of action and microbial metrics of association and identified effective ways to modify the microbiome in many diseases and treatment modalities. This Review explores recent advances in the clinical application of microbiome research over the past 5 years, while acknowledging existing barriers and highlighting opportunities. We focus on the translation of microbiome research into clinical practice, spearheaded by Food and Drug Administration (FDA)-approved microbiome therapies for recurrent Clostridioides difficile infections and the emerging fields of microbiome-based diagnostics and therapeutics. We highlight key examples of studies demonstrating how microbiome mechanisms, metrics and modifiers can advance clinical practice. We also discuss forward-looking perspectives on key challenges and opportunities toward integrating microbiome data into routine clinical practice, precision medicine and personalized healthcare and nutrition.

Note: 2025 Apr;31(4):1099-1113

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Contributing Institute(s):

1. Mikrobiom und Krebs (D480)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 80 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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