TY  - JOUR
AU  - Gilbert, Jack A
AU  - Azad, Meghan B
AU  - Bäckhed, Fredrik
AU  - Blaser, Martin J
AU  - Byndloss, Mariana
AU  - Chiu, Charles Y
AU  - Chu, Hiutung
AU  - Dugas, Lara R
AU  - Elinav, Eran
AU  - Gibbons, Sean M
AU  - Gilbert, Katharine E
AU  - Henn, Matthew R
AU  - Ishaq, Suzanne L
AU  - Ley, Ruth E
AU  - Lynch, Susan V
AU  - Segal, Eran
AU  - Spector, Tim D
AU  - Strandwitz, Philip
AU  - Suez, Jotham
AU  - Tropini, Carolina
AU  - Whiteson, Katrine
AU  - Knight, Rob
TI  - Clinical translation of microbiome research.
JO  - Nature medicine
VL  - 31
IS  - 4
SN  - 1078-8956
CY  - [New York, NY]
PB  - Springer Nature
M1  - DKFZ-2025-00781
SP  - 1099-1113
PY  - 2025
N1  - 2025 Apr;31(4):1099-1113
AB  - The landscape of clinical microbiome research has dramatically evolved over the past decade. By leveraging in vivo and in vitro experimentation, multiomic approaches and computational biology, we have uncovered mechanisms of action and microbial metrics of association and identified effective ways to modify the microbiome in many diseases and treatment modalities. This Review explores recent advances in the clinical application of microbiome research over the past 5 years, while acknowledging existing barriers and highlighting opportunities. We focus on the translation of microbiome research into clinical practice, spearheaded by Food and Drug Administration (FDA)-approved microbiome therapies for recurrent Clostridioides difficile infections and the emerging fields of microbiome-based diagnostics and therapeutics. We highlight key examples of studies demonstrating how microbiome mechanisms, metrics and modifiers can advance clinical practice. We also discuss forward-looking perspectives on key challenges and opportunities toward integrating microbiome data into routine clinical practice, precision medicine and personalized healthcare and nutrition.
LB  - PUB:(DE-HGF)16
C6  - pmid:40217076
DO  - DOI:10.1038/s41591-025-03615-9
UR  - https://inrepo02.dkfz.de/record/300347
ER  -