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@ARTICLE{LaBelle:300772,
      author       = {J. J. LaBelle and R. D. Haase and A. Beck and J. Haase and
                      L. Jiang and C. A. Oliveira de Biagi and S. Neyazi and B.
                      Englinger and I. Liu and M. Trissal and D. Jeong and O. A.
                      Hack and A. Nascimento and M. L. Shaw and C. M. Nguyen and
                      S. Castellani and N. D. Mathewson and O. Ashenberg and G. A.
                      Veiga Cruzeiro and T. Rosenberg and J. R. Vogelzang and J.
                      Pyrdol and S. Marx and A. M. Luomo and A. Godicelj and A.
                      Baumgartner and J. S. Rozowsky and S. Madlener and L. Mayr
                      and A. Peyrl and R. Geyeregger and D. Loetsch and C. Dorfer
                      and C. Haberler and N. Stepien and I. Slavc and T. B.
                      Davidson and R. M. Prins and K. K. Yeo and T. Cooney and K.
                      Ligon and H. Lidov and S. Alexandrescu and L. C. Baird and
                      J. Gojo$^*$ and K. W. Wucherpfennig and M. G. Filbin},
      title        = {{D}issecting the immune landscape in pediatric high-grade
                      glioma reveals cell state changes under therapeutic
                      pressure.},
      journal      = {Cell reports / Medicine},
      volume       = {6},
      number       = {5},
      issn         = {2666-3791},
      address      = {Cambridge, MA},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2025-00920},
      pages        = {102095},
      year         = {2025},
      note         = {Volume 6, Issue 5, 20 May 2025, 102095},
      abstract     = {Pediatric high-grade gliomas (pHGGs) are among the most
                      lethal childhood tumors. While therapeutic approaches were
                      largely adapted from adult treatment regime, significant
                      biological differences between pediatric and adult gliomas
                      exist, which influence the immune microenvironment and may
                      contribute to the limited response to current pHGG treatment
                      strategies. We provide a comprehensive transcriptomic
                      analysis of the pHGG immune landscape using single-cell RNA
                      sequencing and spatial transcriptomics. We analyze matched
                      malignant, myeloid, and T cells from patients with pediatric
                      diffuse high-grade glioma (HGG) or high-grade ependymoma,
                      examining immune microenvironment distinctions after
                      chemo-/radiotherapy, immune checkpoint inhibition treatment,
                      and by age. Our analysis reveals differences in the
                      proportions of pediatric myeloid subpopulations compared to
                      adult counterparts. Additionally, we observe significant
                      shifts toward immune-suppressive environments following
                      cancer therapy. Our findings offer valuable insights into
                      potential immunotherapy targets and serve as a robust
                      resource for understanding immune microenvironmental
                      variations across HGG age groups and treatment regimens.},
      keywords     = {immuno-oncology (Other) / pediatric high-grade glioma
                      (Other) / single-cell RNA-seq (Other) / tumor
                      microenvironment (Other) / tumor-infiltrating immune cell
                      biology (Other)},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40315846},
      doi          = {10.1016/j.xcrm.2025.102095},
      url          = {https://inrepo02.dkfz.de/record/300772},
}