%0 Journal Article
%A Pepin, Mark E
%A Konrad, Philipp J M
%A Nazir, Sumra
%A Bazgir, Farhad
%A Maack, Christoph
%A Nickel, Alexander
%A Gorman, Joshua
%A Hohl, Mathias
%A Schreiter, Friederike
%A Dewenter, Matthias
%A de Britto Chaves Filho, Adriano
%A Schulze, Almut
%A Karlstaedt, Anja
%A Frey, Norbert
%A Seidman, Christine
%A Seidman, Jonathan
%A Backs, Johannes
%T Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.
%J Circulation research
%V 136
%N 12
%@ 0009-7330
%C New York, NY
%I Assoc.
%M DKFZ-2025-00957
%P 1564-1578
%D 2025
%Z 2025 Jun 6;136(12):1564-1578
%X Clinical management of heart failure with preserved ejection fraction (HFpEF) is hindered by a lack of disease-modifying therapies capable of altering its distinct pathophysiology. Despite the widespread implementation of a 2-hit model of cardiometabolic HFpEF to inform precision therapy, which utilizes ad libitum high-fat diet and 0.5
%K NG-nitroarginine methyl ester (Other)
%K fibrosis (Other)
%K genetic therapy (Other)
%K heart failure (Other)
%K oxidative stress (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40340422
%R 10.1161/CIRCRESAHA.125.326154
%U https://inrepo02.dkfz.de/record/301272