TY  - JOUR
AU  - Pepin, Mark E
AU  - Konrad, Philipp J M
AU  - Nazir, Sumra
AU  - Bazgir, Farhad
AU  - Maack, Christoph
AU  - Nickel, Alexander
AU  - Gorman, Joshua
AU  - Hohl, Mathias
AU  - Schreiter, Friederike
AU  - Dewenter, Matthias
AU  - de Britto Chaves Filho, Adriano
AU  - Schulze, Almut
AU  - Karlstaedt, Anja
AU  - Frey, Norbert
AU  - Seidman, Christine
AU  - Seidman, Jonathan
AU  - Backs, Johannes
TI  - Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.
JO  - Circulation research
VL  - 136
IS  - 12
SN  - 0009-7330
CY  - New York, NY
PB  - Assoc.
M1  - DKFZ-2025-00957
SP  - 1564-1578
PY  - 2025
N1  - 2025 Jun 6;136(12):1564-1578
AB  - Clinical management of heart failure with preserved ejection fraction (HFpEF) is hindered by a lack of disease-modifying therapies capable of altering its distinct pathophysiology. Despite the widespread implementation of a 2-hit model of cardiometabolic HFpEF to inform precision therapy, which utilizes ad libitum high-fat diet and 0.5
KW  - NG-nitroarginine methyl ester (Other)
KW  - fibrosis (Other)
KW  - genetic therapy (Other)
KW  - heart failure (Other)
KW  - oxidative stress (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40340422
DO  - DOI:10.1161/CIRCRESAHA.125.326154
UR  - https://inrepo02.dkfz.de/record/301272
ER  -