TY  - JOUR
AU  - Ruiz, Fernanda
AU  - Rispoli, Rossella
AU  - Jaunmuktane, Zane
AU  - Merve, Ashirwad
AU  - D'Antona, Linda
AU  - Dutt, Monika
AU  - Sahm, Felix
AU  - Brandner, Sebastian
TI  - Testing Meningiomas With Methylation Arrays: Insights and Recommendations From a Large Single-Centre Study.
JO  - Neuropathology & applied neurobiology
VL  - 51
IS  - 3
SN  - 0305-1846
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DKFZ-2025-00974
SP  - e70018
PY  - 2025
AB  - Meningiomas are common primary CNS tumours, and their morphological diagnosis is usually straightforward. Their histological grading according to CNS WHO criteria alone provides limited information on recurrence risk. Risk stratification of meningiomas combining WHO grade, methylation class and copy number profile improves prediction of the risk of early recurrence. Because of the frequency of meningiomas in diagnostic practice, applying this prediction algorithm to all meningiomas is financially not viable in most healthcare systems.We analysed a retrospective dataset of over 1000 meningiomas from a single centre with methylation arrays to provide guidance on which meningiomas to prioritise for integrated molecular testing and to understand how WHO grades resolve into risk strata.Approximately 90
KW  - Humans
KW  - Meningioma: genetics
KW  - Meningioma: pathology
KW  - Meningioma: diagnosis
KW  - Meningeal Neoplasms: genetics
KW  - Meningeal Neoplasms: pathology
KW  - Meningeal Neoplasms: diagnosis
KW  - Female
KW  - Male
KW  - DNA Methylation
KW  - Retrospective Studies
KW  - Middle Aged
KW  - Aged
KW  - Adult
KW  - Neoplasm Grading
KW  - Aged, 80 and over
KW  - CNS WHO grading (Other)
KW  - meningioma (Other)
KW  - methylation array (Other)
KW  - model score (Other)
KW  - prognostication (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40356449
DO  - DOI:10.1111/nan.70018
UR  - https://inrepo02.dkfz.de/record/301290
ER  -