guest ::
| Home > Publications database > Testing Meningiomas With Methylation Arrays: Insights and Recommendations From a Large Single-Centre Study. |
| Home > Publications database > Testing Meningiomas With Methylation Arrays: Insights and Recommendations From a Large Single-Centre Study. |
| Journal Article | DKFZ-2025-00974 |
; ; ; ; ; ; ;
2025
Wiley-Blackwell
Oxford [u.a.]
This record in other databases: 
Please use a persistent id in citations: doi:10.1111/nan.70018
Abstract: Meningiomas are common primary CNS tumours, and their morphological diagnosis is usually straightforward. Their histological grading according to CNS WHO criteria alone provides limited information on recurrence risk. Risk stratification of meningiomas combining WHO grade, methylation class and copy number profile improves prediction of the risk of early recurrence. Because of the frequency of meningiomas in diagnostic practice, applying this prediction algorithm to all meningiomas is financially not viable in most healthcare systems.We analysed a retrospective dataset of over 1000 meningiomas from a single centre with methylation arrays to provide guidance on which meningiomas to prioritise for integrated molecular testing and to understand how WHO grades resolve into risk strata.Approximately 90% of CNS WHO Grade 1 meningiomas were allocated into the methylation class 'benign' and also into a low-risk group. Grade 2 meningiomas were allocated almost equally to either the low-risk (39%) or intermediate-risk groups (46%) but occasionally also to the high-risk group (15%). All grading criteria for CNS WHO Grade 2 meningiomas (brain invasion, mitotic count, cytoarchitectural atypia and histological type) showed a similar risk score distribution as the entire group. Grade 3 meningiomas were allocated to intermediate- (26%) or high-risk groups (74%).Our data suggest that Grade 2 and 3 meningiomas should be prioritised for methylation profiling. A small proportion of Grade 1 meningiomas may also benefit from integrated molecular analysis, and further research is needed to explore if those histologically benign meningiomas with a predicted increased recurrence risk are associated with distinct demographic or histological characteristics.
Keyword(s): Humans (MeSH) ; Meningioma: genetics (MeSH) ; Meningioma: pathology (MeSH) ; Meningioma: diagnosis (MeSH) ; Meningeal Neoplasms: genetics (MeSH) ; Meningeal Neoplasms: pathology (MeSH) ; Meningeal Neoplasms: diagnosis (MeSH) ; Female (MeSH) ; Male (MeSH) ; DNA Methylation (MeSH) ; Retrospective Studies (MeSH) ; Middle Aged (MeSH) ; Aged (MeSH) ; Adult (MeSH) ; Neoplasm Grading (MeSH) ; Aged, 80 and over (MeSH) ; CNS WHO grading ; meningioma ; methylation array ; model score ; prognostication
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |
