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000301316 1001_ $$00000-0002-3515-0434$$aPerçin, Gülce$$b0
000301316 245__ $$aEmbryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool.
000301316 260__ $$a[London]$$bSpringer Nature$$c2025
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000301316 520__ $$aEmbryonic macrophages emerge before the onset of definitive hematopoiesis, seed into discrete tissues and contribute to specialized resident macrophages throughout life. Presence of embryonic macrophages in the bone marrow and functional impact on hematopoietic stem cells (HSC) or the niche remains unclear. Here we show that bone marrow macrophages consist of two ontogenetically distinct cell populations from embryonic and adult origin. Newborn mice lacking embryonic macrophages have decreased HSC numbers in the bone marrow suggesting an important function for embryo-derived macrophages in orchestrating HSC trafficking around birth. The establishment of a normal cellular niche space in the bone marrow critically depends on embryonic macrophages that are important for the development of mesenchymal stromal cells, but not other non-hematopoietic niche cells, providing evidence for a specific role for embryo-derived macrophages in the establishment of the niche environment pivotal for the establishment of a normally sized HSC pool.
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000301316 650_2 $$2MeSH$$aAnimals
000301316 650_2 $$2MeSH$$aHematopoietic Stem Cells: cytology
000301316 650_2 $$2MeSH$$aHematopoietic Stem Cells: physiology
000301316 650_2 $$2MeSH$$aMacrophages: cytology
000301316 650_2 $$2MeSH$$aMacrophages: metabolism
000301316 650_2 $$2MeSH$$aMacrophages: physiology
000301316 650_2 $$2MeSH$$aStem Cell Niche: physiology
000301316 650_2 $$2MeSH$$aMice
000301316 650_2 $$2MeSH$$aHomeostasis
000301316 650_2 $$2MeSH$$aHematopoiesis
000301316 650_2 $$2MeSH$$aMice, Inbred C57BL
000301316 650_2 $$2MeSH$$aEmbryo, Mammalian: cytology
000301316 650_2 $$2MeSH$$aMesenchymal Stem Cells: cytology
000301316 650_2 $$2MeSH$$aAnimals, Newborn
000301316 650_2 $$2MeSH$$aFemale
000301316 650_2 $$2MeSH$$aBone Marrow Cells: cytology
000301316 7001_ $$00009-0002-9881-7563$$aRiege, Konstantin$$b1
000301316 7001_ $$00000-0002-4958-6343$$aFröbel, Julia$$b2
000301316 7001_ $$0P:(DE-He78)e3d545b495baa948d017675e0a03ea02$$aMetz, Jonas$$b3$$udkfz
000301316 7001_ $$00000-0001-9837-2811$$aCulemann, Stephan$$b4
000301316 7001_ $$00000-0002-3274-7163$$aLesche, Mathias$$b5
000301316 7001_ $$00000-0001-9202-105X$$aReinhardt, Susanne$$b6
000301316 7001_ $$0P:(DE-He78)9dbe272aaadbdc810ab0bb291eae428e$$aHöfer, Thomas$$b7$$udkfz
000301316 7001_ $$00000-0002-5239-7201$$aHoffmann, Steve$$b8
000301316 7001_ $$00000-0003-3261-0922$$aWaskow, Claudia$$b9
000301316 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-59059-9$$gVol. 16, no. 1, p. 4428$$n1$$p4428$$tNature Communications$$v16$$x2041-1723$$y2025
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