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| Home > Publications database > Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool. |
| Home > Publications database > Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool. |
| Journal Article | DKFZ-2025-00988 |
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2025
Springer Nature
[London]
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Please use a persistent id in citations: doi:10.1038/s41467-025-59059-9
Abstract: Embryonic macrophages emerge before the onset of definitive hematopoiesis, seed into discrete tissues and contribute to specialized resident macrophages throughout life. Presence of embryonic macrophages in the bone marrow and functional impact on hematopoietic stem cells (HSC) or the niche remains unclear. Here we show that bone marrow macrophages consist of two ontogenetically distinct cell populations from embryonic and adult origin. Newborn mice lacking embryonic macrophages have decreased HSC numbers in the bone marrow suggesting an important function for embryo-derived macrophages in orchestrating HSC trafficking around birth. The establishment of a normal cellular niche space in the bone marrow critically depends on embryonic macrophages that are important for the development of mesenchymal stromal cells, but not other non-hematopoietic niche cells, providing evidence for a specific role for embryo-derived macrophages in the establishment of the niche environment pivotal for the establishment of a normally sized HSC pool.
Keyword(s): Animals (MeSH) ; Hematopoietic Stem Cells: cytology (MeSH) ; Hematopoietic Stem Cells: physiology (MeSH) ; Macrophages: cytology (MeSH) ; Macrophages: metabolism (MeSH) ; Macrophages: physiology (MeSH) ; Stem Cell Niche: physiology (MeSH) ; Mice (MeSH) ; Homeostasis (MeSH) ; Hematopoiesis (MeSH) ; Mice, Inbred C57BL (MeSH) ; Embryo, Mammalian: cytology (MeSH) ; Mesenchymal Stem Cells: cytology (MeSH) ; Animals, Newborn (MeSH) ; Female (MeSH) ; Bone Marrow Cells: cytology (MeSH)
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