Journal Article

DKFZ-2025-01053

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genomic landscape of multiple myeloma and its precursor conditions.

Alberge, J.-B. ; Dutta, A. K. ; Poletti, A. ; Coorens, T. H. H. ; Lightbody, E. D. ; Toenges, R. ; Loinaz, X. ; Wallin, S. ; Dunford, A. ; Priebe, O. ; Dagan, J. ; Boehner, C. J. ; Horowitz, E. ; Su, N. K. ; Barr, H. ; Hevenor, L. ; Towle, K. ; Beesam, R. ; Beckwith, J. B. ; Perry, J. ; Cordas Dos Santos, D. M. ; Bertamini, L. ; Greipp, P. T. ; Kübler, K.DKFZ* ; Arndt, P. F. ; Terragna, C. ; Zamagni, E. ; Boyle, E. M. ; Yong, K. ; Morgan, G. ; Walker, B. A. ; Dimopoulos, M. A. ; Kastritis, E. ; Hess, J. ; Sklavenitis-Pistofidis, R. ; Stewart, C. ; Getz, G. ; Ghobrial, I. M.

2025
Macmillan Publishers Limited, part of Springer Nature London

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Please use a persistent id in citations: doi:10.1038/s41588-025-02196-0

Abstract: Reliable strategies to capture patients at risk of progression from precursor stages of multiple myeloma (MM) to overt disease are still missing. We assembled a comprehensive collection of MM genomic data comprising 1,030 patients (218 with precursor conditions) that we used to identify recurrent coding and non-coding candidate drivers as well as significant hotspots of structural variation. We used those drivers to define and validate a simple 'MM-like' score, which we could use to place patients' tumors on a gradual axis of progression toward active disease. Our MM precursor genomic map provides insights into the time of initiation and cell-of-origin of the disease, order of acquisition of genomic alterations and mutational processes found across the stages of transformation. Taken together, we highlight here the potential of genome sequencing to better inform risk assessment and monitoring of MM precursor conditions.

Note: 2025 Jun;57(6):1493-1503

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 30 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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