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| Home > Publications database > Performance of a smartphone-based stool test for use in colorectal cancer screening: population-based study. |
| Journal Article | DKFZ-2025-01063 |
; ; ;
2026
Elsevier Science
New York, NY
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Please use a persistent id in citations: doi:10.1016/j.cgh.2025.04.027
Abstract: Non-invasive colorectal cancer (CRC) screening bears high potential for increasing participation if implemented in a straightforward way. We have evaluated the feasibility and diagnostic performance of a smartphone-based fecal immunochemical test (FIT) for CRC screening and compared its performance of with a laboratory-based FIT.Individuals scheduled for a screening colonoscopy in gastroenterology practices in Southern Germany enrolled into the BLITZ study between 2021 and 2023 were offered a smartphone-based FIT and a laboratory FIT. The smartphone-based FIT consists of a rapid test and a smartphone app. The app quantitatively evaluates the result of the rapid test using the smartphone camera.. The feasibility of the smartphone-based FIT was evaluated in a self-administered questionnaire. The comparative performance of the two FITs was evaluated by sensitivity, specificity and receiver-operator curve (ROC) measures.Of 654 study participants who were offered both a smartphone-based FIT in addition to the laboratory FIT, 361 (55%) made use of the smartphone-based FIT, 274 (76%) of those had a valid smartphone-based FIT, and 643 (98%) used the laboratory FIT. Overall 89% considered the smartphone-based FIT as a useful alternative offer to the laboratory FIT. The reasons why the smartphone-based FIT was not used were mostly technical (app- or smartphone-related, 47%), or reflecting more general concerns or attitudes towards such a test (44%). The smartphone-based FIT showed a sensitivity for advanced neoplasms (28%, 95% confidence interval 13-47%) similar to the laboratory FIT (34%, 18-54%) at an identical specificity (92%, 87-95%).The smartphone-based FIT could serve as an alternative in addition to currently offered laboratory FITs. drks.de, DRKS00008737.
Keyword(s): FIT ; colonoscopy ; digital prevention ; early detection ; self-test
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