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@ARTICLE{Bulanov:301567,
      author       = {P. Bulanov$^*$ and P. Menshchikov$^*$ and J. Grimm$^*$ and
                      M. Lutz and S. Orzada$^*$ and P. Boyd$^*$ and P. Bachert$^*$
                      and M. Ladd$^*$ and A. Korzowski$^*$ and S. Schmitter$^*$},
      title        = {{H}uman liver {CEST} imaging at 7 {T}: {I}mpact of {B} 1 +
                      shimming.},
      journal      = {Magnetic resonance in medicine},
      volume       = {94},
      number       = {4},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2025-01075},
      pages        = {1604-1615},
      year         = {2025},
      note         = {#EA:E020#LA:E020# / Volume 94, Issue 4 pp. 1604-1615},
      abstract     = {To explore the feasibility of CEST imaging in the human
                      liver at 7 T with B 1 + $$ {B}_1^{+} $$ shimming.CEST MRI
                      was performed on a 7 T whole-body scanner with a parallel
                      transmission (pTx) system in five healthy volunteers. Static
                      pTx ( B 1 + $$ {B}_1^{+} $$ shimming) was applied to locally
                      maximize the B 1 + $$ {B}_1^{+} $$ magnitude per input power
                      within a given region of interest (ROI) of approximately 30
                      mm diameter (ROIshim). Relaxation-compensated inverse
                      magnetization transfer ratio (MTRRex) values were quantified
                      for amide protons, guanidino protons, and relayed nuclear
                      Overhauser effect signals based on five-pool Lorentzian fit
                      analysis. MTRRex values were corrected for B1
                      inhomogeneities using an absolute, accurate MR
                      fingerprinting-based B 1 + $$ {B}_1^{+} $$ mapping
                      technique.Within the ROIshim, reliable MTRRex values could
                      be calculated for an average of 85\% of voxels. The mean
                      MTRRex values and corresponding coefficient of variations
                      across the group are: 0.113 ± 0.009, 8.8\% for amide; 0.167
                      ± 0.010, 6.3\% for nuclear Overhauser effect; and 0.079 ±
                      0.010, 12.9\% for guanidino. MTRRex values exhibit low
                      variation between subjects, as reflected by low coefficient
                      of variations.In this study, we have demonstrated for the
                      first time the feasibility of acquiring and quantifying
                      relaxation-compensated CEST contrasts in the human liver at
                      ultrahigh field. The application of static pTx effectively
                      eliminates B 1 + $$ {B}_1^{+} $$ dropouts and allows for
                      accurate CEST contrast quantification within the selected
                      ROI. In addition, the proposed B 1 + $$ {B}_1^{+} $$ mapping
                      technique shows efficacy for enhanced MTRRex B1 corrections
                      in the abdomen.},
      keywords     = {7 T (Other) / B1 correction (Other) / B1+ B 1 + $$
                      {B}_1^{+} $$ shimming (Other) / body CEST (Other) / liver
                      CEST (Other) / pTx (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40411372},
      doi          = {10.1002/mrm.30557},
      url          = {https://inrepo02.dkfz.de/record/301567},
}