TY  - JOUR
AU  - Onkes, Meike
AU  - Dahlmann, Paul
AU  - Gesenhues, Alena
AU  - Gacula, Sean Ira G
AU  - Mansour, Nabeel
AU  - Schweizer, Júnia R O L
AU  - Stüfchen, Isabel
AU  - Lottspeich, Christian
AU  - Wang, Katharina
AU  - Auer, Matthias K
AU  - Brendel, Matthias
AU  - Fischer, Alessa
AU  - Braunschweig, Till
AU  - Gildehaus, Franz-Josef
AU  - Lindner, Simon
AU  - Schmid-Tannwald, Christine
AU  - Pfluger, Thomas
AU  - Auernhammer, Christoph J
AU  - Nölting, Svenja
AU  - Werner, Rudolf A
AU  - Reincke, Martin
AU  - Bidlingmaier, Martin
AU  - Kroiss, Matthias
AU  - Völter, Friederike
TI  - [18F]SiTATE-PET/CT for detection of pheochromocytomas and paragangliomas: comparison of biochemical secretion, genotype and imaging metrics.
JO  - European journal of nuclear medicine and molecular imaging
VL  - nn
SN  - 1619-7070
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - DKFZ-2025-01128
SP  - nn
PY  - 2025
N1  - epub
AB  - Somatostatin-receptor (SSTR)-targeting PET/CT is widely used for diagnosis and disease monitoring of pheochromocytoma / paraganglioma (PPGL). The aim of this study was to assess the potential of the novel SSTR-targeting tracer [18F]SiTATE in diagnosing PPGL by comparing imaging parameters to tumor marker levels and secretory activity in a small cohort of patients diagnosed with this rare tumor type.This retrospective study included 34 patients with histologically confirmed PPGL who underwent [18F]SiTATE-PET/CT at LMU University Hospital Munich between 10/2020 and 02/2024 as well as hormonal laboratory analysis within up to 100 days. Imaging parameters - standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), and total lesion uptake (TLU) - were analyzed. Uptake was normalized to liver background (SUVmaxr, SUVmeanr). Radioligand uptake of biochemical subtypes and genotypes was compared with Mann-Whitney-U test. Correlation was tested using Spearman´s rank correlation test.The patient-based detection rate of [18F]SiTATE-PET was 96.6
KW  - Catecholamines (Other)
KW  - ELISA (Other)
KW  - LCMS (Other)
KW  - Molecular imaging (Other)
KW  - PET/CT (Other)
KW  - PPGL (Other)
KW  - Paraganglioma (Other)
KW  - Pheochromocytoma (Other)
KW  - SSTR (Other)
KW  - [18F]SiTATE (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40445313
DO  - DOI:10.1007/s00259-025-07341-9
UR  - https://inrepo02.dkfz.de/record/301744
ER  -