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@ARTICLE{Fu:301906,
      author       = {Z. Fu and L. Borho and S. E. Taylor and L. E. Kelemen and
                      A. DeFazio and P. M. Webb and M. Köbel and N. S. Meagher
                      and R. Na and A. C. Antoniou and A. H. Brand and C. J.
                      Kennedy and N. Nevins and P. D. P. Pharoah and Y. B.
                      Shvetsov and S. J. Winham and J. Alsop and M. W. Beckmann
                      and A. Bolithon and J. Boros and D. D. L. Bowtell and J. D.
                      Brenton and M. E. Carney and A. Chudecka-Głaz and L. S.
                      Cook and C. Cybulski and P. A. Fasching and S. Fereday and
                      R. T. Fortner$^*$ and M. J. García and E. L. Goode and M.
                      T. Goodman and J. Gronwald and A. Hartmann and B. Y.
                      Hernandez and E. Høgdall and D. G. Huntsman and A. Jensen
                      and M. Jimenez-Linan and J. M. Joseph and B. Y. Karlan and
                      E. Kaznowska and S. K. Kjaer and T. Kluz and J. M. Koziak
                      and J. Lester and T. A. Longacre and M. Lycke and V. McGuire
                      and K. B. Moysich and R. A. Murphy and S. Orsulic and S. J.
                      Ramus and C. Rodríguez-Antona and J. H. Rothstein and S.
                      Samra and W. Sieh and H. Steed and K. Sundfeldt and A.
                      Talhouk and J. Uciński and C. Wang and N. Wentzensen and A.
                      S. Whittemore and L. R. Wilkens and T. Songer and M. M.
                      Brooks and L. Tang and F. Modugno},
      title        = {{O}varian cancer risk and survival according to tumor sex
                      hormone receptor expression: {A}n ovarian {C}ancer
                      association consortium and ovarian tumor tissue analysis
                      consortium pooled analysis.},
      journal      = {Gynecologic oncology},
      volume       = {198},
      issn         = {0090-8258},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2025-01176},
      pages        = {112 - 129},
      year         = {2025},
      abstract     = {Many epithelial ovarian cancer (EOC) risk factors relate to
                      sex hormones. The association between these factors and the
                      expression of androgen receptor (AR), estrogen receptor-α
                      (ER), and progesterone receptor (PR) in tumors is unknown.We
                      linked epidemiologic, AR/ER/PR tumor expression, and
                      survival data from 19 studies in the Ovarian Cancer
                      Association Consortium (OCAC; 4762 cases, 20,888 controls)
                      and the Ovarian Tumor Tissue Analysis (OTTA) consortium
                      (5737 cases). We estimated odds ratios (ORs) and 95 $\%$
                      confidence intervals (CIs) between hormonally-linked factors
                      and tumor AR/ER/PR expression using polytomous logistic
                      regression. We assessed survival by AR/ER/PR tumor
                      expression overall and by histotype using Kaplan-Meier
                      curves and Cox proportional hazards
                      models.Overweight/obesity was associated with higher risk of
                      ER- tumors (OR:1.53, 95 $\%$ I:1.18-1.98). Hysterectomy was
                      associated with greater risk of ER+ tumors (OR:4.99, 95 $\%$
                      CI:4.27-5.83), which varied by AR expression (Pheter=0.003).
                      Postmenopause was associated with a higher risk of PR-
                      tumors (OR 1.52, 95 $\%$ CI 1.26-1.83), which varied based
                      by AR (Pheter < 0.001) and ER (Pheter < 0.001) expression.
                      Gravidity, oral contraception duration, and breastfeeding
                      duration showed differing dose-response relationships
                      according to AR/ER/PR expression. Hormone therapy use,
                      postmenopause, physical inactivity, and being
                      obese/overweight prior to diagnosis were differentially
                      associated with survival based on AR/ER/PR expression and
                      histotype.EOC has varying risk and prognostic profiles
                      depending on both histotype and AR/ER/PR expression.
                      Biological mechanisms underlying the association between
                      hormonally-linked factors and EOC need to be studied by both
                      histotypes and by AR, ER, and PR expression.},
      keywords     = {Epithelial ovarian cancer (Other) / Hormonal factors
                      (Other) / Hormone receptor (Other) / Risk (Other) / Survival
                      (Other) / androgen receptor (Other) / estrogen receptor
                      (Other) / progesterone receptor (Other)},
      cin          = {C180},
      ddc          = {610},
      cid          = {I:(DE-He78)C180-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40482607},
      doi          = {10.1016/j.ygyno.2025.05.013},
      url          = {https://inrepo02.dkfz.de/record/301906},
}