Journal Article

DKFZ-2025-01176

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ovarian cancer risk and survival according to tumor sex hormone receptor expression: An ovarian Cancer association consortium and ovarian tumor tissue analysis consortium pooled analysis.

Fu, Z. ; Borho, L. ; Taylor, S. E. ; Kelemen, L. E. ; DeFazio, A. ; Webb, P. M. ; Köbel, M. ; Meagher, N. S. ; Na, R. ; Antoniou, A. C. ; Brand, A. H. ; Kennedy, C. J. ; Nevins, N. ; Pharoah, P. D. P. ; Shvetsov, Y. B. ; Winham, S. J. ; Alsop, J. ; Beckmann, M. W. ; Bolithon, A. ; Boros, J. ; Bowtell, D. D. L. ; Brenton, J. D. ; Carney, M. E. ; Chudecka-Głaz, A. ; Cook, L. S. ; Cybulski, C. ; Fasching, P. A. ; Fereday, S. ; Fortner, R. T.DKFZ* ; García, M. J. ; Goode, E. L. ; Goodman, M. T. ; Gronwald, J. ; Hartmann, A. ; Hernandez, B. Y. ; Høgdall, E. ; Huntsman, D. G. ; Jensen, A. ; Jimenez-Linan, M. ; Joseph, J. M. ; Karlan, B. Y. ; Kaznowska, E. ; Kjaer, S. K. ; Kluz, T. ; Koziak, J. M. ; Lester, J. ; Longacre, T. A. ; Lycke, M. ; McGuire, V. ; Moysich, K. B. ; Murphy, R. A. ; Orsulic, S. ; Ramus, S. J. ; Rodríguez-Antona, C. ; Rothstein, J. H. ; Samra, S. ; Sieh, W. ; Steed, H. ; Sundfeldt, K. ; Talhouk, A. ; Uciński, J. ; Wang, C. ; Wentzensen, N. ; Whittemore, A. S. ; Wilkens, L. R. ; Songer, T. ; Brooks, M. M. ; Tang, L. ; Modugno, F.

2025
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.ygyno.2025.05.013

Abstract: Many epithelial ovarian cancer (EOC) risk factors relate to sex hormones. The association between these factors and the expression of androgen receptor (AR), estrogen receptor-α (ER), and progesterone receptor (PR) in tumors is unknown.We linked epidemiologic, AR/ER/PR tumor expression, and survival data from 19 studies in the Ovarian Cancer Association Consortium (OCAC; 4762 cases, 20,888 controls) and the Ovarian Tumor Tissue Analysis (OTTA) consortium (5737 cases). We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) between hormonally-linked factors and tumor AR/ER/PR expression using polytomous logistic regression. We assessed survival by AR/ER/PR tumor expression overall and by histotype using Kaplan-Meier curves and Cox proportional hazards models.Overweight/obesity was associated with higher risk of ER- tumors (OR:1.53, 95 % I:1.18-1.98). Hysterectomy was associated with greater risk of ER+ tumors (OR:4.99, 95 % CI:4.27-5.83), which varied by AR expression (Pheter=0.003). Postmenopause was associated with a higher risk of PR- tumors (OR 1.52, 95 % CI 1.26-1.83), which varied based by AR (Pheter < 0.001) and ER (Pheter < 0.001) expression. Gravidity, oral contraception duration, and breastfeeding duration showed differing dose-response relationships according to AR/ER/PR expression. Hormone therapy use, postmenopause, physical inactivity, and being obese/overweight prior to diagnosis were differentially associated with survival based on AR/ER/PR expression and histotype.EOC has varying risk and prognostic profiles depending on both histotype and AR/ER/PR expression. Biological mechanisms underlying the association between hormonally-linked factors and EOC need to be studied by both histotypes and by AR, ER, and PR expression.

Keyword(s): Epithelial ovarian cancer ; Hormonal factors ; Hormone receptor ; Risk ; Survival ; androgen receptor ; estrogen receptor ; progesterone receptor

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Contributing Institute(s):

1. Krebsepidemiologie (C180)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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