%0 Journal Article
%A Brenner, Hermann
%A Sergeev, Dmitry
%A Heisser, Thomas
%A Hoffmeister, Michael
%T Research Communication: Effects of Screening Colonoscopyon Colorectal Cancer Mortality: Lessons From ComparativeAnalyses of Randomised Trials
%J Alimentary pharmacology & therapeutics
%V 62
%N 6
%@ 0269-2813
%C Oxford
%I Blackwell Science
%M DKFZ-2025-01184
%P 656-659
%D 2025
%Z #EA:C070#LA:C070# / 2025 Sep;62(6):656-659
%X NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with those of NORCCAP, a similarly designed pragmatic sigmoidoscopy trial. In NORCCAP, differences in CRC mortality only began to emerge after 9.5 years of follow-up, rapidly increased thereafter and were approximately 4-fold as high after 12 years than after 10 years. Other sigmoidoscopy trials yielded similar 11- to 12-year results. Our analysis suggests that the apparent negative CRC mortality results of NordICC primarily reflect insufficient follow-up time.
%K colonoscopy (Other)
%K colorectal cancer (Other)
%K mortality (Other)
%K screening (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40492318
%R DOI:10.1111/apt.70231
%U https://inrepo02.dkfz.de/record/301914