Journal Article

DKFZ-2025-01184

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Research Communication: Effects of Screening Colonoscopyon Colorectal Cancer Mortality: Lessons From ComparativeAnalyses of Randomised Trials

Brenner, H. (First author)DKFZ* ; Sergeev, D.DKFZ* ; Heisser, T.DKFZ* ; Hoffmeister, M. (Last author)DKFZ*

2025
Blackwell Science Oxford

This record in other databases:  

Please use a persistent id in citations: doi:10.1111/apt.70231  doi:DOI:10.1111/apt.70231

Abstract: NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with those of NORCCAP, a similarly designed pragmatic sigmoidoscopy trial. In NORCCAP, differences in CRC mortality only began to emerge after 9.5 years of follow-up, rapidly increased thereafter and were approximately 4-fold as high after 12 years than after 10 years. Other sigmoidoscopy trials yielded similar 11- to 12-year results. Our analysis suggests that the apparent negative CRC mortality results of NordICC primarily reflect insufficient follow-up time.

Keyword(s): colonoscopy ; colorectal cancer ; mortality ; screening

Note: #EA:C070#LA:C070# / 2025 Sep;62(6):656-659

---

Contributing Institute(s):

1. C070 Klinische Epidemiologie der Krebsfrüherkennung (C070)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---