TY  - JOUR
AU  - Brenner, Hermann
AU  - Sergeev, Dmitry
AU  - Heisser, Thomas
AU  - Hoffmeister, Michael
TI  - Research Communication: Effects of Screening Colonoscopyon Colorectal Cancer Mortality: Lessons From ComparativeAnalyses of Randomised Trials
JO  - Alimentary pharmacology & therapeutics
VL  - 62
IS  - 6
SN  - 0269-2813
CY  - Oxford
PB  - Blackwell Science
M1  - DKFZ-2025-01184
SP  - 656-659
PY  - 2025
N1  - #EA:C070#LA:C070# / 2025 Sep;62(6):656-659
AB  - NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with those of NORCCAP, a similarly designed pragmatic sigmoidoscopy trial. In NORCCAP, differences in CRC mortality only began to emerge after 9.5 years of follow-up, rapidly increased thereafter and were approximately 4-fold as high after 12 years than after 10 years. Other sigmoidoscopy trials yielded similar 11- to 12-year results. Our analysis suggests that the apparent negative CRC mortality results of NordICC primarily reflect insufficient follow-up time.
KW  - colonoscopy (Other)
KW  - colorectal cancer (Other)
KW  - mortality (Other)
KW  - screening (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40492318
DO  - DOI:DOI:10.1111/apt.70231
UR  - https://inrepo02.dkfz.de/record/301914
ER  -