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@ARTICLE{Runge:302011,
      author       = {S. Runge and S. von Zedtwitz and A. M. Maucher and P. Bruno
                      and L. Osbelt and B. Zhao and A. M. Gernand and T. R. Lesker
                      and K. Gräwe and M. Rogg and C. Schell and M. Boerries$^*$
                      and T. Strowig and G. Andrieux and B. Hild and S. P.
                      Rosshart},
      title        = {{L}aboratory mice engrafted with natural gut microbiota
                      possess a wildling-like phenotype.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-01209},
      pages        = {5301},
      year         = {2025},
      abstract     = {Conventional laboratory mice housed under specific
                      pathogen-free (SPF) conditions are the standard model in
                      biomedical research. However, in recent years, many
                      rodent-based studies have been deemed irreproducible,
                      raising questions about the suitability of mice as model
                      organisms. Emerging evidence indicates that variability in
                      SPF microbiota plays a significant role in data
                      inconsistencies across laboratories. Although efforts have
                      been made to standardize microbiota, existing microbial
                      consortia lack the complexity and resilience necessary to
                      replicate interactions in free-living mammals. We present a
                      robust, feasible and standardizable approach for
                      transplanting natural gut microbiota from wildlings into
                      laboratory mice. Following engraftment, these TXwildlings
                      adopt a structural and functional wildling-like microbiota
                      and host physiology toward a more mature immune system, with
                      characteristics similar to those of adult humans. We
                      anticipate that adopting wild mouse-derived microbiota as
                      standard for laboratory mouse models will improve the
                      reproducibility and generalizability of basic and
                      preclinical biomedical research.},
      keywords     = {Animals / Gastrointestinal Microbiome: immunology /
                      Gastrointestinal Microbiome: physiology / Mice / Phenotype /
                      Specific Pathogen-Free Organisms / Mice, Inbred C57BL / Male
                      / Female / Fecal Microbiota Transplantation: methods /
                      Models, Animal},
      cin          = {FR01},
      ddc          = {500},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40506454},
      doi          = {10.1038/s41467-025-60554-2},
      url          = {https://inrepo02.dkfz.de/record/302011},
}