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| Home > Publications database > Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype. |
| Home > Publications database > Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype. |
| Journal Article | DKFZ-2025-01209 |
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2025
Springer Nature
[London]
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Please use a persistent id in citations: doi:10.1038/s41467-025-60554-2
Abstract: Conventional laboratory mice housed under specific pathogen-free (SPF) conditions are the standard model in biomedical research. However, in recent years, many rodent-based studies have been deemed irreproducible, raising questions about the suitability of mice as model organisms. Emerging evidence indicates that variability in SPF microbiota plays a significant role in data inconsistencies across laboratories. Although efforts have been made to standardize microbiota, existing microbial consortia lack the complexity and resilience necessary to replicate interactions in free-living mammals. We present a robust, feasible and standardizable approach for transplanting natural gut microbiota from wildlings into laboratory mice. Following engraftment, these TXwildlings adopt a structural and functional wildling-like microbiota and host physiology toward a more mature immune system, with characteristics similar to those of adult humans. We anticipate that adopting wild mouse-derived microbiota as standard for laboratory mouse models will improve the reproducibility and generalizability of basic and preclinical biomedical research.
Keyword(s): Animals (MeSH) ; Gastrointestinal Microbiome: immunology (MeSH) ; Gastrointestinal Microbiome: physiology (MeSH) ; Mice (MeSH) ; Phenotype (MeSH) ; Specific Pathogen-Free Organisms (MeSH) ; Mice, Inbred C57BL (MeSH) ; Male (MeSH) ; Female (MeSH) ; Fecal Microbiota Transplantation: methods (MeSH) ; Models, Animal (MeSH)
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