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@ARTICLE{Sirtl:302790,
      author       = {S. Sirtl and B. Teodorescu$^*$ and L. Gilberg and A.
                      Schäfer and G. Beyer and A. Arnau and P. López-Guillén
                      and S. J. Martínez-Domínguez and D. A. Baroja and D. Oyón
                      and L. M. Ruiz-Belmonte and J. Tejedor-Tejada and R. Zapater
                      and N. Martín-Vicente and P. J. Fernández-Esparcia and A.
                      B. J. Gomara and V. S. Lozano and J. J. M. García and I. C.
                      Martín-Falquina and L. A. Pascual and N. T. Monclus and N.
                      Z. Velasco and E. Rojo and B. Lapeña-Muñoz and V. Flores
                      and A. D. Gómez and P. Cañamares-Orbís and I. V. Abizanda
                      and N. M. Carrasco and L. P. Grau and G. García-Rayado and
                      J. M. Bocos and A. G. G. de Paredes and M. V. Lorenzo and A.
                      I. Arostegi and E. E. Lozada-Hernández and J. A. V. Velasco
                      and M. Żorniak and E. de-Madaria and J. Mayerle and R.
                      Velamazán},
      title        = {{L}ower rate of pancreatobiliary complications after sludge
                      and microlithiasis pancreatitis compared to gallstone
                      pancreatitis.},
      journal      = {Digestive and liver disease},
      volume       = {57},
      number       = {9},
      issn         = {1590-8658},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2025-01330},
      pages        = {1810-1818},
      year         = {2025},
      note         = {Volume 57, Issue 9, September 2025, Pages 1810-1818},
      abstract     = {Cholecystectomy is recommended to prevent recurrence of
                      biliary pancreatitis, but supporting evidence is limited for
                      sludge- and microlithiasis-induced acute pancreatitis (AP).
                      This study aimed to compare relapse patterns and risk
                      factors between patients with sludge/microlithiasis-induced
                      AP and gallstone-induced AP.This analysis included 789
                      patients from the international, multicenter Relapstone
                      cohort (Spain: 16 centers; Mexico: 2 centers), hospitalized
                      between January 2018 and April 2020 with first-time biliary
                      AP and no cholecystectomy during admission. Patients with
                      sludge/microlithiasis-induced AP (n = 274) were compared to
                      those with gallstone-induced AP (n = 515) regarding
                      pancreatobiliary complications. Multivariate analysis was
                      used to assess relapse risk factors.Pancreatobiliary
                      complications occurred in 41.7 $\%$ of the gallstone cohort
                      versus 32.1 $\%$ in the sludge/microlithiasis cohort (p =
                      0.01). Correspondingly, the gallstone AP cohort showed a
                      significantly lower complication-free survival rate
                      (log-rank p = 0.0022; median follow-up: 6.1 vs. 8.1 months).
                      In multivariate analysis, older age in the gallstone group
                      was significantly associated with lower relapse risk (HR =
                      0.54, 95 $\%$ CI: 0.39-0.74).This multicenter study reveals
                      distinct differences in relapse risk between gallstone- and
                      sludge/microlithiasis-induced AP, with gallstone AP showing
                      a higher rate of complications in the absence of
                      cholecystectomy.},
      keywords     = {Acute pancreatitis (Other) / Biliary pancreatitis (Other) /
                      Gallstones (Other) / Microlithiasis (Other) / Sludge
                      (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40582954},
      doi          = {10.1016/j.dld.2025.06.005},
      url          = {https://inrepo02.dkfz.de/record/302790},
}