Journal Article

DKFZ-2025-01330

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lower rate of pancreatobiliary complications after sludge and microlithiasis pancreatitis compared to gallstone pancreatitis.

Sirtl, S. ; Teodorescu, B.DKFZ* ; Gilberg, L. ; Schäfer, A. ; Beyer, G. ; Arnau, A. ; López-Guillén, P. ; Martínez-Domínguez, S. J. ; Baroja, D. A. ; Oyón, D. ; Ruiz-Belmonte, L. M. ; Tejedor-Tejada, J. ; Zapater, R. ; Martín-Vicente, N. ; Fernández-Esparcia, P. J. ; Gomara, A. B. J. ; Lozano, V. S. ; García, J. J. M. ; Martín-Falquina, I. C. ; Pascual, L. A. ; Monclus, N. T. ; Velasco, N. Z. ; Rojo, E. ; Lapeña-Muñoz, B. ; Flores, V. ; Gómez, A. D. ; Cañamares-Orbís, P. ; Abizanda, I. V. ; Carrasco, N. M. ; Grau, L. P. ; García-Rayado, G. ; Bocos, J. M. ; de Paredes, A. G. G. ; Lorenzo, M. V. ; Arostegi, A. I. ; Lozada-Hernández, E. E. ; Velasco, J. A. V. ; Żorniak, M. ; de-Madaria, E. ; Mayerle, J. ; Velamazán, R.

2025
Saunders [Erscheinungsort nicht ermittelbar]

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Please use a persistent id in citations: doi:10.1016/j.dld.2025.06.005

Abstract: Cholecystectomy is recommended to prevent recurrence of biliary pancreatitis, but supporting evidence is limited for sludge- and microlithiasis-induced acute pancreatitis (AP). This study aimed to compare relapse patterns and risk factors between patients with sludge/microlithiasis-induced AP and gallstone-induced AP.This analysis included 789 patients from the international, multicenter Relapstone cohort (Spain: 16 centers; Mexico: 2 centers), hospitalized between January 2018 and April 2020 with first-time biliary AP and no cholecystectomy during admission. Patients with sludge/microlithiasis-induced AP (n = 274) were compared to those with gallstone-induced AP (n = 515) regarding pancreatobiliary complications. Multivariate analysis was used to assess relapse risk factors.Pancreatobiliary complications occurred in 41.7 % of the gallstone cohort versus 32.1 % in the sludge/microlithiasis cohort (p = 0.01). Correspondingly, the gallstone AP cohort showed a significantly lower complication-free survival rate (log-rank p = 0.0022; median follow-up: 6.1 vs. 8.1 months). In multivariate analysis, older age in the gallstone group was significantly associated with lower relapse risk (HR = 0.54, 95 % CI: 0.39-0.74).This multicenter study reveals distinct differences in relapse risk between gallstone- and sludge/microlithiasis-induced AP, with gallstone AP showing a higher rate of complications in the absence of cholecystectomy.

Keyword(s): Acute pancreatitis ; Biliary pancreatitis ; Gallstones ; Microlithiasis ; Sludge

Note: Volume 57, Issue 9, September 2025, Pages 1810-1818

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Contributing Institute(s):

1. DKTK Koordinierungsstelle München (MU01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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