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@ARTICLE{Yuan:302810,
      author       = {T. Yuan$^*$ and K. E. Tagscherer and W. Roth and M.
                      Bewerunge-Hudler$^*$ and A. Brobeil and M. Kloor and H.
                      Bläker and H. Brenner$^*$ and M. Hoffmeister$^*$},
      title        = {{M}ethylation-based smoking signatures in blood and tissue
                      samples for the prediction of self-reported smoking status
                      and mortality in patients with colorectal cancer.},
      journal      = {Clinical epigenetics},
      volume       = {17},
      number       = {1},
      issn         = {1868-7075},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2025-01350},
      pages        = {113},
      year         = {2025},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Smoking is a well-established risk factor for colorectal
                      cancer (CRC) development. However, the reliability of DNA
                      methylation-based smoking signatures in predicting smoking
                      status and their prognostic value in CRC remain unclear,
                      particularly across different biological sample types.Five
                      previously validated methylation-based smoking signatures
                      were analyzed in 2237 CRC patients with blood-derived DNA
                      and 2273 patients with tumor tissue-derived DNA.
                      Blood-derived signatures showed strong correlations with
                      self-reported smoking status, effectively differentiating
                      current smokers from never smokers (all p < 0.0001), with
                      excellent discriminative ability (median area under the
                      receiver operating characteristic curve: 0.94). In contrast,
                      tumor tissue-derived signatures exhibited much weaker
                      associations with smoking status. Among non-metastatic CRC
                      patients, blood-derived methylation signatures were
                      significantly associated with increased risks of all-cause
                      and non-CRC-related mortality, but not with CRC-specific
                      mortality. Conversely, two tumor tissue-derived signatures
                      demonstrated stronger associations with CRC-specific
                      mortality compared to blood-derived signatures.Blood-derived
                      methylation-based smoking signatures are robust indicators
                      for smoking exposure and are associated with increased
                      mortality risk among non-metastatic CRC patients. When
                      applied to tumor tissue, signatures showed stronger
                      associations with CRC-specific mortality.},
      keywords     = {Humans / Colorectal Neoplasms: genetics / Colorectal
                      Neoplasms: mortality / Colorectal Neoplasms: blood / DNA
                      Methylation / Male / Female / Middle Aged / Smoking:
                      genetics / Smoking: adverse effects / Smoking: blood / Self
                      Report / Aged / Prognosis / Risk Factors / Colorectal cancer
                      (Other) / DNA methylation biomarkers (Other) / Prognosis
                      (Other) / Smoking (Other)},
      cin          = {W110 / HD01 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)W110-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40611182},
      pmc          = {pmc:PMC12225191},
      doi          = {10.1186/s13148-025-01918-9},
      url          = {https://inrepo02.dkfz.de/record/302810},
}