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| Home > Publications database > Methylation-based smoking signatures in blood and tissue samples for the prediction of self-reported smoking status and mortality in patients with colorectal cancer. |
| Home > Publications database > Methylation-based smoking signatures in blood and tissue samples for the prediction of self-reported smoking status and mortality in patients with colorectal cancer. |
| Journal Article | DKFZ-2025-01350 |
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2025
BioMed Central
[Erscheinungsort nicht ermittelbar]
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Please use a persistent id in citations: doi:10.1186/s13148-025-01918-9
Abstract: Smoking is a well-established risk factor for colorectal cancer (CRC) development. However, the reliability of DNA methylation-based smoking signatures in predicting smoking status and their prognostic value in CRC remain unclear, particularly across different biological sample types.Five previously validated methylation-based smoking signatures were analyzed in 2237 CRC patients with blood-derived DNA and 2273 patients with tumor tissue-derived DNA. Blood-derived signatures showed strong correlations with self-reported smoking status, effectively differentiating current smokers from never smokers (all p < 0.0001), with excellent discriminative ability (median area under the receiver operating characteristic curve: 0.94). In contrast, tumor tissue-derived signatures exhibited much weaker associations with smoking status. Among non-metastatic CRC patients, blood-derived methylation signatures were significantly associated with increased risks of all-cause and non-CRC-related mortality, but not with CRC-specific mortality. Conversely, two tumor tissue-derived signatures demonstrated stronger associations with CRC-specific mortality compared to blood-derived signatures.Blood-derived methylation-based smoking signatures are robust indicators for smoking exposure and are associated with increased mortality risk among non-metastatic CRC patients. When applied to tumor tissue, signatures showed stronger associations with CRC-specific mortality.
Keyword(s): Humans (MeSH) ; Colorectal Neoplasms: genetics (MeSH) ; Colorectal Neoplasms: mortality (MeSH) ; Colorectal Neoplasms: blood (MeSH) ; DNA Methylation (MeSH) ; Male (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Smoking: genetics (MeSH) ; Smoking: adverse effects (MeSH) ; Smoking: blood (MeSH) ; Self Report (MeSH) ; Aged (MeSH) ; Prognosis (MeSH) ; Risk Factors (MeSH) ; Colorectal cancer ; DNA methylation biomarkers ; Prognosis ; Smoking
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