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| 024 | 7 | _ | |a 1868-7075 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2025-01350 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Yuan, Tanwei |0 P:(DE-He78)b9e439a1aa1244925f92d547c0919349 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Methylation-based smoking signatures in blood and tissue samples for the prediction of self-reported smoking status and mortality in patients with colorectal cancer. |
| 260 | _ | _ | |a [Erscheinungsort nicht ermittelbar] |c 2025 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:C070#LA:C070# |
| 520 | _ | _ | |a Smoking is a well-established risk factor for colorectal cancer (CRC) development. However, the reliability of DNA methylation-based smoking signatures in predicting smoking status and their prognostic value in CRC remain unclear, particularly across different biological sample types.Five previously validated methylation-based smoking signatures were analyzed in 2237 CRC patients with blood-derived DNA and 2273 patients with tumor tissue-derived DNA. Blood-derived signatures showed strong correlations with self-reported smoking status, effectively differentiating current smokers from never smokers (all p < 0.0001), with excellent discriminative ability (median area under the receiver operating characteristic curve: 0.94). In contrast, tumor tissue-derived signatures exhibited much weaker associations with smoking status. Among non-metastatic CRC patients, blood-derived methylation signatures were significantly associated with increased risks of all-cause and non-CRC-related mortality, but not with CRC-specific mortality. Conversely, two tumor tissue-derived signatures demonstrated stronger associations with CRC-specific mortality compared to blood-derived signatures.Blood-derived methylation-based smoking signatures are robust indicators for smoking exposure and are associated with increased mortality risk among non-metastatic CRC patients. When applied to tumor tissue, signatures showed stronger associations with CRC-specific mortality. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a Colorectal cancer |2 Other |
| 650 | _ | 7 | |a DNA methylation biomarkers |2 Other |
| 650 | _ | 7 | |a Prognosis |2 Other |
| 650 | _ | 7 | |a Smoking |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Colorectal Neoplasms: genetics |2 MeSH |
| 650 | _ | 2 | |a Colorectal Neoplasms: mortality |2 MeSH |
| 650 | _ | 2 | |a Colorectal Neoplasms: blood |2 MeSH |
| 650 | _ | 2 | |a DNA Methylation |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Smoking: genetics |2 MeSH |
| 650 | _ | 2 | |a Smoking: adverse effects |2 MeSH |
| 650 | _ | 2 | |a Smoking: blood |2 MeSH |
| 650 | _ | 2 | |a Self Report |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Prognosis |2 MeSH |
| 650 | _ | 2 | |a Risk Factors |2 MeSH |
| 700 | 1 | _ | |a Tagscherer, Katrin E |b 1 |
| 700 | 1 | _ | |a Roth, Wilfried |b 2 |
| 700 | 1 | _ | |a Bewerunge-Hudler, Melanie |0 P:(DE-He78)7999346780553d7fab7ba69d5afdfa71 |b 3 |u dkfz |
| 700 | 1 | _ | |a Brobeil, Alexander |b 4 |
| 700 | 1 | _ | |a Kloor, Matthias |b 5 |
| 700 | 1 | _ | |a Bläker, Hendrik |b 6 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 7 |u dkfz |
| 700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1186/s13148-025-01918-9 |g Vol. 17, no. 1, p. 113 |0 PERI:(DE-600)2553921-8 |n 1 |p 113 |t Clinical epigenetics |v 17 |y 2025 |x 1868-7075 |
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