%0 Journal Article
%A Ursprung, Stephan
%A Zender, Lars
%A Ghibes, Patrick
%A Hagen, Florian
%A Nikolaou, Konstantin
%A la Fougère, Christian
%A Weissinger, Matthias
%T Variability of Metabolic Rate and Distribution Volume Quantification in Whole-Body Parametric PATLAK [18F]-FDG PET/CT-A Prospective Trial in Patients with Lung Cancer.
%J Diagnostics
%V 15
%N 13
%@ 2075-4418
%C Basel
%I MDPI
%M DKFZ-2025-01379
%P 1719
%D 2025
%X Background: The recent introduction of whole-body positron emission tomography/ computed tomography (PET/CT) scanners and multi-bed, multi-time point acquisition technique enable calculating fluorodeoxyglucose (FDG) kinetics in the whole body. However, validating parametric, Patlak-derived data is difficult on phantoms. Methods: This prospective study investigated the effect of quantification methods mean, max, and peak on the metabolic rate (MR-FDG) and distribution volume (DV-FDG) quantification, as well as the diagnostic accuracy of parametric Patlak FDG-PET scans in diagnosing lung lesions and lymph node metastases, using histopathology and follow-up as reference standards. Dynamic whole-body FDG PET was acquired for 80 minutes in 34 patients with indeterminate lung lesions and kinetic parameters extracted from lung lesions and representative mediastinal and hilar lymph nodes. Results: All quantification methods-mean, max, and peak-demonstrated high diagnostic accuracy (AUC: MR-FDG: 0.987-0.991 and 0.893-0.905; DV-FDG: 0.948-0.975 and 0.812-0.825) for differentiating benign from malignant lymph nodes and lung lesions. Differences in the magnitude of MR-FDG (-4.76-14.09) and DV-FDG (-10.64-46.10
%K FDG (Other)
%K PET/CT (Other)
%K Patlak (Other)
%K dynamic PET (Other)
%K parametric FDG (Other)
%K whole-body (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40647718
%2 pmc:PMC12249058
%R 10.3390/diagnostics15131719
%U https://inrepo02.dkfz.de/record/302839