TY  - JOUR
AU  - Ursprung, Stephan
AU  - Zender, Lars
AU  - Ghibes, Patrick
AU  - Hagen, Florian
AU  - Nikolaou, Konstantin
AU  - la Fougère, Christian
AU  - Weissinger, Matthias
TI  - Variability of Metabolic Rate and Distribution Volume Quantification in Whole-Body Parametric PATLAK [18F]-FDG PET/CT-A Prospective Trial in Patients with Lung Cancer.
JO  - Diagnostics
VL  - 15
IS  - 13
SN  - 2075-4418
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-01379
SP  - 1719
PY  - 2025
AB  - Background: The recent introduction of whole-body positron emission tomography/ computed tomography (PET/CT) scanners and multi-bed, multi-time point acquisition technique enable calculating fluorodeoxyglucose (FDG) kinetics in the whole body. However, validating parametric, Patlak-derived data is difficult on phantoms. Methods: This prospective study investigated the effect of quantification methods mean, max, and peak on the metabolic rate (MR-FDG) and distribution volume (DV-FDG) quantification, as well as the diagnostic accuracy of parametric Patlak FDG-PET scans in diagnosing lung lesions and lymph node metastases, using histopathology and follow-up as reference standards. Dynamic whole-body FDG PET was acquired for 80 minutes in 34 patients with indeterminate lung lesions and kinetic parameters extracted from lung lesions and representative mediastinal and hilar lymph nodes. Results: All quantification methods-mean, max, and peak-demonstrated high diagnostic accuracy (AUC: MR-FDG: 0.987-0.991 and 0.893-0.905; DV-FDG: 0.948-0.975 and 0.812-0.825) for differentiating benign from malignant lymph nodes and lung lesions. Differences in the magnitude of MR-FDG (-4.76-14.09) and DV-FDG (-10.64-46.10
KW  - FDG (Other)
KW  - PET/CT (Other)
KW  - Patlak (Other)
KW  - dynamic PET (Other)
KW  - parametric FDG (Other)
KW  - whole-body (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40647718
C2  - pmc:PMC12249058
DO  - DOI:10.3390/diagnostics15131719
UR  - https://inrepo02.dkfz.de/record/302839
ER  -