%0 Journal Article
%A Kubik, András
%A das Virgens, Isabel Pinto Amorim
%A Varga, Nóra
%A Szabó, Anett
%A Keszthelyi, Attila
%A Fehérvári, Péter
%A Hegyi, Péter
%A Ács, Nándor
%A Nyirády, Péter
%A Szarvas, Tibor
%T Radical Surgery Compared to Bladder-Preserving Approaches for Limited Stage Small-Cell Bladder Cancer: Systematic Review and Meta-Analysis.
%J Clinical genitourinary cancer
%V nn
%@ 1558-7673
%C Dallas, Tex.
%I CIG Media Group
%M DKFZ-2025-01398
%P nn
%D 2025
%Z epub
%X Small-cell bladder cancer (SCBC) is an aggressive and rare malignancy for which there is no clear optimal treatment strategy. This systematic review and meta-analysis aimed to compare the median overall survival (OS) of patients with limited-stage (LS) SCBC treated with either cystectomy-based multimodal therapy (CBMMT) or radiation-based multimodal therapy (RBMMT).A comprehensive search of PUBMED, Embase, and Scopus databases was performed for studies published before January 2024 according to the PRISMA guidelines. Studies have assessed LS-SCBC disease and provided survival data for subgroups of patients undergoing radical surgery or bladder-preserving approaches to be deemed eligible. Data extraction and quality assessment were independently conducted by 2 authors.Five studies comprising 1041 patients were analyzed. The pooled median OS for patients receiving RBMMT was 34.6 months (95
%K Bladder cancer (Other)
%K Chemotherapy (Other)
%K Neuroendocrine tumor (Other)
%K Radical cystectomy (Other)
%K Small-cell tumor (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40664516
%R 10.1016/j.clgc.2025.102389
%U https://inrepo02.dkfz.de/record/302858