%0 Journal Article
%A Hensel, Astrid
%A Váraljai, Renáta
%A Knauer, Shirley K
%T Raising the iron curtain: Lactate's secret role in oxidative stress defense.
%J Redox Biology
%V 85
%@ 2213-2317
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2025-01401
%P 103754
%D 2025
%X The hypothesis presented here is that certain cell types under oxidative stress, such as cancer cells, reprogram their metabolism to accumulate lactate, along with cytosolic Fe2+ within the labile iron pool, thereby establishing a metabolite-based H2O2 detoxification system. In this scenario, the Fenton reaction between Fe2+ and H2O2 generates hydroxyl radicals (HO•), which are subsequently scavenged by abundant lactate. Thus, lactate production may function as a protective, iron-dependent antioxidant mechanism, enabling cells to decompose H2O2 and prevent damage to crucial biomolecules. If this system is compromised, for instance by inadequate HO•-scavenging or impaired Fe2+ recycling, cells may become prone to ferroptosis.
%K Fenton reaction (Other)
%K Ferroptosis (Other)
%K Labile iron pool (Other)
%K Lactate (Other)
%K Oxidative stress (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40663910
%R 10.1016/j.redox.2025.103754
%U https://inrepo02.dkfz.de/record/302861