Journal Article (Review Article)

DKFZ-2025-01401

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Raising the iron curtain: Lactate's secret role in oxidative stress defense.

Hensel, A. ; Váraljai, R.DKFZ* ; Knauer, S. K.

2025
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.redox.2025.103754

Abstract: The hypothesis presented here is that certain cell types under oxidative stress, such as cancer cells, reprogram their metabolism to accumulate lactate, along with cytosolic Fe2+ within the labile iron pool, thereby establishing a metabolite-based H2O2 detoxification system. In this scenario, the Fenton reaction between Fe2+ and H2O2 generates hydroxyl radicals (HO•), which are subsequently scavenged by abundant lactate. Thus, lactate production may function as a protective, iron-dependent antioxidant mechanism, enabling cells to decompose H2O2 and prevent damage to crucial biomolecules. If this system is compromised, for instance by inadequate HO•-scavenging or impaired Fe2+ recycling, cells may become prone to ferroptosis.

Keyword(s): Fenton reaction ; Ferroptosis ; Labile iron pool ; Lactate ; Oxidative stress

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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