TY  - JOUR
AU  - Hensel, Astrid
AU  - Váraljai, Renáta
AU  - Knauer, Shirley K
TI  - Raising the iron curtain: Lactate's secret role in oxidative stress defense.
JO  - Redox Biology
VL  - 85
SN  - 2213-2317
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2025-01401
SP  - 103754
PY  - 2025
AB  - The hypothesis presented here is that certain cell types under oxidative stress, such as cancer cells, reprogram their metabolism to accumulate lactate, along with cytosolic Fe2+ within the labile iron pool, thereby establishing a metabolite-based H2O2 detoxification system. In this scenario, the Fenton reaction between Fe2+ and H2O2 generates hydroxyl radicals (HO•), which are subsequently scavenged by abundant lactate. Thus, lactate production may function as a protective, iron-dependent antioxidant mechanism, enabling cells to decompose H2O2 and prevent damage to crucial biomolecules. If this system is compromised, for instance by inadequate HO•-scavenging or impaired Fe2+ recycling, cells may become prone to ferroptosis.
KW  - Fenton reaction (Other)
KW  - Ferroptosis (Other)
KW  - Labile iron pool (Other)
KW  - Lactate (Other)
KW  - Oxidative stress (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40663910
DO  - DOI:10.1016/j.redox.2025.103754
UR  - https://inrepo02.dkfz.de/record/302861
ER  -