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@ARTICLE{Hensel:302861,
      author       = {A. Hensel and R. Váraljai$^*$ and S. K. Knauer},
      title        = {{R}aising the iron curtain: {L}actate's secret role in
                      oxidative stress defense.},
      journal      = {Redox Biology},
      volume       = {85},
      issn         = {2213-2317},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-01401},
      pages        = {103754},
      year         = {2025},
      abstract     = {The hypothesis presented here is that certain cell types
                      under oxidative stress, such as cancer cells, reprogram
                      their metabolism to accumulate lactate, along with cytosolic
                      Fe2+ within the labile iron pool, thereby establishing a
                      metabolite-based H2O2 detoxification system. In this
                      scenario, the Fenton reaction between Fe2+ and H2O2
                      generates hydroxyl radicals (HO•), which are subsequently
                      scavenged by abundant lactate. Thus, lactate production may
                      function as a protective, iron-dependent antioxidant
                      mechanism, enabling cells to decompose H2O2 and prevent
                      damage to crucial biomolecules. If this system is
                      compromised, for instance by inadequate HO•-scavenging or
                      impaired Fe2+ recycling, cells may become prone to
                      ferroptosis.},
      subtyp        = {Review Article},
      keywords     = {Fenton reaction (Other) / Ferroptosis (Other) / Labile iron
                      pool (Other) / Lactate (Other) / Oxidative stress (Other)},
      cin          = {ED01},
      ddc          = {570},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40663910},
      doi          = {10.1016/j.redox.2025.103754},
      url          = {https://inrepo02.dkfz.de/record/302861},
}