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| 005 | 20250731103659.0 | ||
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| 100 | 1 | _ | |a Rejeski, Kai |0 0000-0003-3905-0251 |b 0 |
| 245 | _ | _ | |a Noncanonical and mortality-defining toxicities of CAR T cell therapy. |
| 260 | _ | _ | |a [New York, NY] |c 2025 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2025 Jul;31(7):2132-2146 |
| 520 | _ | _ | |a Chimeric antigen receptor (CAR) T cell therapy is associated with a unique spectrum of toxicities that drive morbidity, mortality and patient quality of life. Previous efforts yielded consensus grading systems for the prototypical immunotoxicities-namely, cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). These grading systems set the stage for severity-based and standardized treatment protocols that have contributed to a reduction in the acute toxicity burden of CAR T cell therapy and have enabled outpatient administration. However, understanding of CAR T cell therapy has since grown to encompass new targets, new diseases and broader patient populations-including long-term survivors. As side effects are better defined and novel toxicities emerge, there is a need to understand their mechanisms and standardize reporting to improve clinical management. Here we review the current state of knowledge for mortality-defining and rare toxicities of CAR T cell therapies, beyond CRS and ICANS. We discuss mechanisms, including on-target injury, cytokine-associated inflammation and dysregulated recovery, and how these mechanisms affect the timing and management of toxicities. Finally, we define key unmet needs and delineate future priorities and research directions. |
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| 700 | 1 | _ | |a Hill, Joshua A |0 0000-0002-7665-7100 |b 1 |
| 700 | 1 | _ | |a Dahiya, Saurabh |b 2 |
| 700 | 1 | _ | |a Jain, Michael D |0 0000-0002-7789-1257 |b 3 |
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